Clinical study on endovascular treatment for thrombosis of intracranial venous sinus
WU Guo-de1, ZHANG Zhen-chang1, LI Xin1, LI Jian-xiong1, CAO Hua2, ZHANG Ting-hua1, TENG Qing-lan1, SHI Zheng-hong1, LUO Fu-ming1
1.Lanzhou University Second Hospital, Lanzhou 730030, China;2.Department of Neurology, Chinese Traditional Medicine Hospital of Gansu Province, Lanzhou 730030, China
Abstract：Objective: To observe the effect and safety of combined intravenous and intra-arterial thrombolysis therapy for intracranial venous sinus thrombosis(CVST). Twenty-one patients with CVST who accepted endovascular therapy were analysed retrospectively. Methods: Twenty-one patients diagnosed CVST with CTA, MRA and/or DSA. The time of onset of illness, the treatment history and the curative effect before the therapy were recorded for each patient. Then each of them were treated with multiple modality of endovascular thrombolysis including intra-arterial thrombolysis, intravenous thrombolysis, mechanical thrombus maceration, lied up micro-catheter thrombolysis． The relationship between the operative time and the curative effect, complication and treatment were analysed. Results: CVST reopened in 14 cases, partly reopened in 6 cases and no effect in 1 case. Balloon ruptured in 1 case, in one patient the cerebral superficial vein ruptured without get the surgical repaired at that time, and one week later ruptured again. The effective rate was 95.2%, the rate of complications of the therapy was 9.5%. Follow-up for 1~2 years, no patient recurred except one case. Conclusions: The endovascular therapy is safe and effective in treating patients with CVST, but the course of disease must be within 8 weeks. The shorter the course, the result will be better. Most complications are due to manipulating technique.
2012, Vol. 23 
