Abstract:Objective: To analyze the causes of failure in mammography-guided wire localization stereotactic-biopsy of non-palpable breast lesions. Methods: One hundred and eighty one patients with 192 lesions, which were non-palpable but positive in mammography, were analyzed retrospectively. All the lesions were performed mammography-guided wire localization and then were excised. The removed specimens were sent back to radiology department for mammography and estimated whether the suspected lesions were excised entirely or partially excised and whether re-excision was needed. Results: Among these 192 lesions, there were 176 lesions which were excised fully by one-stage operation. There were 13 lesions which were excised fully by two or more. And 3 lesions were not excised completely at the end. Conclusions: Pay attention to the impact factors is the guarantee of improving successful rate and precise localization of mammography-guided wire localization stereotactic-biopsy.