声触诊组织量化评价颈动脉斑块与脑卒中风险的相关性研究

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摘要目的：探讨声触诊组织量化（Virtual touch tissue quantification，VTQ）技术检测颈动脉斑块弹性剪切波速度（Shear wave velocity，SWV）值与脑卒中初发风险的相关性。方法：连续入选 2017年1—6月于我院行颈动脉超声检查确诊的颈动脉斑块患者98例，超声方法测量每例患者的斑块参数，并根据Framingham卒中量表评分结果分为高危组（n=53例）、非高危组（n=45例），分析其危险因素。结果：二分类多因素非条件Logistic回归分析示，VTQ测得的SWV值、血清肌酐（Cr）、体质量指数（BMI）是脑卒中发病高风险的危险因素，回归系数（B）分别为-1.974，0.414，0.102；95%可信区间（CI）0.026~0.736，1.086~2.105，1.006~1.219；P值0.020，0.014，0.026。多元线性回归分析显示SWV、Cr、低密度脂蛋白（LDL）是影响脑卒中风险评分高低的主要因素，回归系数分别为-1.946，0.075，-2.157；P值0.023，0.000，0.003。与高危组比较，非高危组SWV值明显较高（P<0.01），差异有统计学意义。结论：VTQ测定的弹性值SWV能反映颈动脉斑块的稳定性，可以作为脑卒中发病风险预测评估的有效指标。

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	杨环宇
	杨扬
	任建丽
	王志刚

关键词 ：颈动脉疾病, 脑血管意外, 超声检查

Abstract：Objective: To explore the relationship between the carotid plaque SWV value and the risk of initial stroke. Methods: A total of 98 patients with carotid atherosclerotic plaque and without stroke before in our hospital from January to June 2017 were investigated. Based on the Framingham stroke scale score, the patients were divided into high-risk group(n=53) and non high-risk group(n=45), and the stroke risk factors between groups were compared. Results: Multivariate unconditional Logistic regression analysis showed that SWV, Cr and BMI were the independent risk factors for high risk of stroke (B=-1.974, 0.414, 0.102; 95%CI: 0.026~0.736, 1.086~2.105, 1.006~1.219; P=0.020, 0.014, 0.026, respectively). Multivariate linear regression analysis indicated that SWV, Cr and LDL were related to the severity of stroke risk(B=-1.946, 0.075, -2.157; P=0.023, 0.000, 0.003 respectively). Compared with high-risk group, non high-risk group presented the higher SWV value(P<0.01). Conclusion: The SWV value can reveal the stability of carotid plaque, and it can be used as an effective indicator for prediction and assessment of stroke risk.

Key words： Carotid artery diseases Cerebrovascular accident Ultrasonography

收稿日期: 2017-10-24

PACS:	Ｒ543.4
	Ｒ743.3
	Ｒ445.1

基金资助:国家自然科学基金资助项目（编号81471675）。

通讯作者: 杨扬，重庆医科大学超声影像学研究所重庆医科大学附属第二医院超声科，400010。E-mail：yangyang1983818@163.com

作者简介: 杨环宇（1992-），女，云南宣威人，在读硕士研究生。E-mail：834152954@qq.com

引用本文:

杨环宇，杨扬，任建丽，王志刚. 声触诊组织量化评价颈动脉斑块与脑卒中风险的相关性研究[J]. 中国临床医学影像杂志, 2018, 29(6): 419-422.
YANG Huan-yu, YANG Yang, REN Jian-li, WANG Zhi-gang. Study of correlation between carotid atherosclerotic plaque and stroke by virtual touch tissue quantification. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(6): 419-422.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2018/V29/I6/419

[1]Pereyra M, Dobigeon N, Batatia H, et al. Segmentation of skin lesions in 2D and 3D ultrasound images using a spatially coherent generalized Rayleigh mixture model[J]. IEEE Trans Med Imaging, 2012, 31(8): 1509-1520.
[2]Magge R, Lau BC, Soares BP, et al. Clinical risk factors and CT imaging features of carotid atherosclerotic plaques as predictors of new incident carotid ischemic stroke: a retrospective cohort study[J]. Am J Neuroradiol, 2013, 34(2): 402-409.
[3]中华医学会神经病学分会. 中国缺血性脑卒中风险评估量表使用专家共识[J]. 中华神经科杂志，2016，49（7）：519-525.
[4]Dong L, Underhill HR, Yu W, et al. Geometric and compositional appearance of atheroma in an angiographically normal carotid artery in patients with atherosclerosis[J]. Am J Neuroradiol, 2010, 31(2): 311-316.
[5]Tsuzuki K, Hasegawa H, Ichiki M, et al. Optimal region-of-interest settings for tissue characterization based on ultrasonic elasticity imaging[J]. Ultrasound Med Biol, 2008, 34(4): 573-585.
[6]Naim C, Cloutier G, Mercure E, et al. Characterisation of carotid plaques with ultrasound elastography: feasibility and correlation with high-resolution magnetic resonance imaging[J]. Eur Radiol, 2013, 23(7): 2030-2041.
[7]刘碧英，佘德君，戚婉，等. 基于Essen卒中风险评分的缺血性脑卒中危险度分层的颈动脉斑块特征研究[J]. 磁共振成像，2016，7（10）：738-742.
[8]Howard DP, Van Lammeren GW, Redgrave JN, et al. Histological features of carotid plaque in patients with ocular ischemia versus cerebral events[J]. Stroke, 2013, 44(3): 734-739.
[9]Fleg JL, Stone GW, Fayad ZA, et al. Detection of high-risk atherosclerotic plaque: report of the NHLBI Working Group on current status and future directions[J]. JACC Cardiovasc Imaging, 2012, 5(9): 941-955.
[10]栗静，田婷，石正洪，等. 纤维蛋白原、C反应蛋白及同型半耽氨酸与大动脉粥样硬化型卒中患者颈动脉易损性斑块的相关性分析[J]. 解放军医学杂志，2017，42（1）：41-46.
[11]孙翾，顾敦星. CT血管造影评价颈动脉易损性斑块与症状性缺血性脑卒中关系的价值[J]. 现代中西医结合杂志，2017，26（3）：328-342.
[12]Wentzel JJ, Schuurbiers JC, Gonzalo Lopez N, et al. In vivo assessment of the relationship between shear stress and necrotic core in early and advanced coronary artery disease[J]. Eurointervention, 2013, 9(8): 989-995.
[13]Arai D, Yamaguchi S, Murakami M, et al. Characteristics of carotid plaque finding on ultrasonography and black blood magnetic resonance imaging in comparison with pathological findings[J]. Acta Neurochir Suppl, 2011, 112(1): 15-19.
[14]武晓娟，杨琳，叶秀芳，等. 弹性成像技术诊断脑梗死患者颈动脉斑块[J]. 中国医学影像技术，2014，30（1）：46-48.
[15]翟红燕. 声触诊组织量化技术评价颈动脉粥样硬化斑块与急性冠脉综合征的关系[D]. 天津：天津医科大学，2013.
[16]Gils MJV, Bodde MC, Cremers LGM, et al. Determinants of calcification growth in atherosclerotic carotid arteries: a serial multi-detector CT angiography study[J]. Atherosclerosis, 2013, 227(1): 95-99.