ToF技术在一体化PET/MR体部肿瘤诊断中的初步应用体会

doi:10.12117/jccmi.2018.07.007

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摘要目的：为了评估飞行时间（ToF）技术在一体化PET/MR上图像质量、半定量分析中的临床应用价值。方法：对比研究21例肿瘤患者ToF以及非ToF方法重建的PET图像对于原发肿瘤性病变的显示，标准化摄取值SUV（SUVmax和SUVmean）和信号噪声比（SNR）的差异。结果：通过ToF和非ToF重建获取肿瘤病灶的最大SUV（T-SUVmax）分别为18.37±12.71、17.12±12.17，肿瘤病灶的平均SUV（T-SUVmean）分别为10.17±6.97、9.34±6.58；肝脏或肌肉组织的最大SUV（N-SUVmax）分别为1.71±1.07、1.46±0.82，肝脏或肌肉组织的平均SUV（N-SUVmean）分别为1.24±0.65、1.15±0.66；差异均有统计学意义（P<0.001）。加入ToF技术T-SUVmax和T-SUVmean较非ToF分别升高了9%±5%，10%±4%。加入ToF技术重建的图像相对于未加入ToF技术的图像，SNR分别为ToF=10.59±3.07，非ToF=10.13±3.35，两者之间存在统计学差异（P<0.05）。结论：一体化PET/MR利用ToF技术重建获得的图像在病灶的半定量分析上优于非ToF重建方法，同时ToF可较明显改善图像质量。

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关键词 ：肿瘤, 正电子发射断层显像术

Abstract：Objective: To assess the image quality and clinical evaluation in simultaneous integrated time of flight(ToF) PET/MR. Methods: Twenty-one patients with primary tumors were analyzed, and the ability in lesion recognition and standard uptake value(SUVmax and SUVmean) and signal noise ratio(SNR) between ToF and non-ToF reconstruction method were compared. Results: With ToF and non-ToF reconstruction methods, the maximum SUV of the primary tumors(T-SUVmax) were 18.37±12.71, 17.12±12.17 respectively, and average SUV(T-SUVmean) were 10.17±6.97, 9.34±6.58. The maximum SUV of the normal tissue(N-SUVmax) were 1.71±1.07, 1.46±0.82, and average SUV(N-SUVmean) were 1.24±0.65, 1.15±0.66. The difference of the above four parameters between the two methods were statistically significant(P<0.001). T-SUVmax and T-SUVmean with ToF increased by 9%±5%, 10%±4% compared with non-ToF. The image quality was better with the ToF reconstruction methods. The SNR with ToF was significantly higher than that of non-ToF(ToF, 10.59±3.07 vs. non-ToF, 10.13±3.35, P<0.05). Conclusion: Simultaneous integrated PET/MR can be of great significance and importance with ToF reconstruction in lesion recognition and semi-qualified analysis.

Key words： Neoplasms Positron-emission tomography

收稿日期: 2017-05-11

PACS:	Ｒ730.4
	Ｒ817.4

基金资助:辽宁省教育厅重点实验室基础研究项目（LZ2015079）

通讯作者: 辛军，中国医科大学附属盛京医院影像医学与核医学科，110004。E-mail：xinj@sj-hospital.org

作者简介: 张新（1984-），女，辽宁昌图人，副教授。E-mail：zhangxin_2003@163.com

引用本文:

张新1，郭启勇1，孙洪赞1，王搏1，刘长平1，翟伟1，范夷平1，陈忠维2，辛军1. ToF技术在一体化PET/MR体部肿瘤诊断中的初步应用体会[J]. 中国临床医学影像杂志, 2018, 29(7): 479-482.
ZHANG Xin1, GUO Qi-yong1, SUN Hong-zan1, WANG Bo1, LIU Chang-ping1,. The clinical evaluation of ToF reconstruction in simultaneous integrated PET/MR in the diagnosis of body tumors. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(7): 479-482.

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http://www.jccmi.com.cn/CN/10.12117/jccmi.2018.07.007 或 http://www.jccmi.com.cn/CN/Y2018/V29/I7/479

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