18F-FDG PET/CT在成人Still病中的表现及其评估疾病活动度的作用

doi:10.12117/jccmi.2020.05.015

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：探讨18F-FDG PET/CT在成人Still病（Adult-onset still disease，AOSD）中的表现及其评估疾病活动度的作用。方法：选取确诊为AOSD并进行18F-FDG PET/CT检查的患者46例，收集其临床资料和PET/CT特点，分析AOSD患者的骨髓、脾脏、淋巴结标准化摄取值（Standardized uptake values，SUV）强度与实验室指标、系统评分之间的相关性。结果：AOSD的18F-FDG摄取主要发生于骨髓（100%，SUV强度：2.00±0.66）、脾（96%，SUV强度：1.70±0.54）及淋巴结（98%，SUV强度：2.67±1.38），此外18F-FDG摄取还可发生于心包、胸膜、咽部、颌下腺、腮腺、甲状腺、皮肤、关节、食管、贲门部位。骨髓SUV强度与疾病系统评分、血沉、C-反应蛋白、白细胞计数和中性粒百分数显著相关（r=0.445、0.376、0.323、0.439、0.524，P<0.05）。脾脏SUV强度与疾病系统评分、乳酸脱氢酶显著相关（r=0.424、0.347，P<0.05）。淋巴结SUV强度与疾病系统评分显著相关（r=0.356，P<0.05）。结论：AOSD在18F-FDG PET/CT上主要表现为骨髓、脾脏及淋巴结的FDG高摄取，18F-FDG PET/CT有助于监测疾病活动性。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李施阳
	张晓莉

关键词 ： Still病, 成年型, 正电子发射断层显像术, 体层摄影术, 螺旋计算机

Abstract：Objective: To investigate the expression of 18F-FDG PET/CT in patients with adult-onset Still’s disease (AOSD) and its role in disease activity. Methods: 46 patients who was diagnosed as AOSD were selected and underwent 18F-FDG PET/CT. The clinical manifestations, laboratory examination and characteristics of PET/CT were collected. Then the correlation between SUV intensity of liver, spleen, bone marrow, lymph node and laboratory indexes, system scores were analyzed. Results: 18F-FDG accumulation occurred mainly in bone marrow(100%, SUV intensity: 2.00±0.66), Spleen(96%, SUV intensity:1.70±0.54) and lymph nodes(98%, SUV intensity: 2.67±1.38). In addition, 18F-FDG uptake can also occur in the pericardial pleural, parotid gland, thyroid, skin, joint esophagus and cardia. SUV intensity of bone marrow was significantly correlated with systemic score, ESR, C-reactive protein, WBC and NEU%(r=0.445, 0.376, 0.323, 0.439, 0.524, P<0.05). SUV intensity of spleen was significantly correlated with system score and LDH(r=0.424, 0.347, P<0.05). SUV intensity of lymph node was significantly correlated with disease system score(r=0.356, P<0.05). Conclusion: 18F-FDG accumulation occurred mainly in bone marrow, spleen and lymph nodes. 18F-FDG PET/CT is helpful for the differential diagnosis and monitoring of disease activity.

Key words： Still's disease, adult-onset Positron-emission tomography Tomography, spiral computed

收稿日期: 2019-08-08

PACS:	Ｒ593
	Ｒ817.4

基金资助:辽宁省科学计划项目（编号2015020546）。

通讯作者: 张晓莉，中国医科大学附属盛京医院风湿免疫科，110004。E-mail：zhangxl3@sj-hospital.org

作者简介: 李施阳（1993-），女，湖北仙桃人，在读硕士研究生。E-mail：1850561598@163.com

引用本文:

李施阳，张晓莉. 18F-FDG PET/CT在成人Still病中的表现及其评估疾病活动度的作用[J]. 中国临床医学影像杂志, 2020, 31(5): 368-371.
LI Shi-yang, ZHANG Xiao-li. Imaging of 18F-FDG PET/CT in adult-onset Still’s disease and its role in the assessment of disease activity. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(5): 368-371.

链接本文:

http://www.jccmi.com.cn/CN/10.12117/jccmi.2020.05.015 或 http://www.jccmi.com.cn/CN/Y2020/V31/I5/368

[1]Mahroum N, Mahagna H, Amital H. Diagnosis and classification of adult Still's disease[J]. J Autoimmunity, 2014, 48(49): 34-37.
[2]乔文礼，邢岩，戚勤励. 18F－FDG PET/CT在黏膜相关淋巴组织淋巴瘤分期、中期疗效与预后评估中的价值[J]. 中华核医学与分子影像杂志，2018，38（9）：588.
[3]Yamashita H, Kubota K, Mimori A. Clinical value of whole-body PET/CT in patients with active rheumatic diseases[J]. Arthritis Res Ther, 2014, 16(5): 423.
[4]Yamaguchi M, Ohta A, Tsunematsu T, et al. Preliminary criteria for classification of adult Still’s disease[J]. J Rheumatol, 1992, 19(3): 424-430.
[5]Pouchot J, Sampalis JS, Beaudet F, et al. Adult Still’s disease:manifestations, disease course, and outcome in 62 patients[J]. Medicine(Baltimore), 1991, 70(2): 118-136.
[6]Lee KH, Cho A, Choi YJ, et al. The role of (18)F-fluorodeoxyglucose-positron emission tomography in the assessment of disease activity in patients with Takayasu arteritis[J]. Arthritis Rheum, 2012, 64(5): 866-875.
[7]Kalyoncu U, Solmaz D, Emmungil H, et al. Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort[J]. J Autoimmunity, 2016, 69(5): 59-63.
[8]Arraes AED, Souza AWSD, Mariz HA, et al. 18F-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis[J]. Revista Brasileira De Reumatologia, 2016, 8(7): 2255-2264.
[9]陆东燕，俞浩楠，李彦生，等. 18F-FDG PET/CT评价抗中性粒细胞胞质抗体相关性血管炎的临床价值[J]. 中华核医学与分子影像杂志，2019，6（7）：91-95.
[10]Li Y, Zhou Y, Wang Q. Multiple values of 18F-FDG PET/CT in idiopathic inflammatory myopathy[J]. Clin Rheumatol, 2017, 36(10): 2297-2305.
[11]Yamashita H, Kubota K, Takahashi Y, et al. Clinical value of 18F-fluoro-dexoxyglucose positron emission tomography/computed tomography in patients with adult-onset Still’s disease: a seven-case series and review of the literature[J]. Mod Rheumatol, 2014, 24(5): 645-650.
[12]Dong MJ, Wang CQ, Zhao K, et al. 18F-FDG PET/CT in patients with adult-onset Still’s disease[J]. Clin Rheumatol, 2015, 34(12): 2047-2056.
[13]Cunha ML, Wagner J, Osawa A, et al. The effect of tocilizumab on the uptake of 18FDG-PET imaging in patients with adult-onset Still's disease[J]. Rheumatology, 2010, 49(5): 1014-1016.
[14]Graaff LCGD, Broek MRJT, Schweitzer DH. Is Still’s disease still one disease? A case of Adult-onset Still’s disease showing accumulation in the carotids and the large vessels of the legs on positron emission tomography: CT images[J]. Rheumatol Intern, 2012, 32(8): 2487-2490.
[15]Ruscitti P, Cipriani P, Masedu F, et al. Adult-onset Still’s disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers[J]. BMC Medicine, 2016, 14(1): 194.
[16]Murata Y, Kubota K, Yukihiro M, et al. Correlations between 18F-FDG uptake by bone marrow and hematological parameters:measurements by PET/CT[J]. Nucl Med Biol, 2006, 33(8): 999-1004.