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| The diagnostic value of the pulmonary perfusion SPECT/CT in detecting pulmonary embolism forpatients due to malignant tumor |
| WU Da-yong1, ZHANG Wen-yan1, CHEN Jiang-hong2, BIAN Yan-zhu1 |
| 1.Department of Nuclear Medicine, Hebei Ceneral Hospital, Shijiazhuang 050051, China;2.Department of Ultrasound, the First Hospital of Hebei Medical University, Shijiazhuang 050050, China |
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Abstract Objective: To retrospectively study the diagnostic value of pulmonary perfusion SPECT/CT in patients suspected of having pulmonary embolism due to malignant tumor. Methods: All the 55 patients suspected of having pulmonary embolism due to malignancy received pulmonary perfusion SPECT/CT in our department from July 1, 2011 to December 1, 2013. The pulmonary perfusion SPECT/CT images were analyzed retrospectively. The standard for diagnosing embolism lung segment were sparse or defective radioactive distribution in a wedge shape lung segment or sub-segment, but no lesions that caused lung perfusion reduced in the corresponding lung on CT images. The final diagnosis of pulmonary thromboembolism(PTE) was confirmed by comprehensive analysis of the patients’ clinical data. The positive rate, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of lung perfusion SPECT/CT in the diagnosis of PTE were calculated. The datas diagnosed by lung perfusion SPECT/CT and by comprehensive analysis of the patients’ clinical data were analyzed by matching four-fold table chi-square test(McNemar test). Results: Among the 55 patients with malignant tumor, 42 cases were diagnosed PTE by pulmonary perfusion SPECT/CT, and 41 cases were diagnosed PTE by comprehensive analysis of the patients’ clinical data. There was no statistical difference of the results diagnosed by pulmonary perfusion SPECT/CT and by comprehensive analysis of the patients’ clinical data (χ2=0.049, P>0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of lung perfusion SPECT/CT in the diagnosis PTE was 94.4%, 85.2%, 89.5%, 92.0%, 90.5% respectively. Conclusion: PTE in patients with malignant tumor can be accurately diagnosed by pulmonary perfusion SPECT/CT which provides a reliable method for diagnosis.
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Received: 10 April 2014
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2014, Vol. 25 
