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| Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma |
| YE Jing1, XU Yi-kai1, LIU Xian2, LU Xue-song1, XU Peng-jun1, HUANG Qi-liu1, JIANG Zhi-qiang1, LV Guo-shi1 |
| 1. Nanfang Hospital, Nanfang Medical University, Guangzhou 510515;2. Department of Radiology, Guangdong Province Traditional Chinese Medicine Hospital, Guangzhou 510102, China |
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Abstract Objective: To investigate MR enhancement of different administration routes in MR pretargeting immunology imaging. Methods: Two groups of mice were injected with SA-DTPA-Gd through tail vein(iv) and intra-peritoneal cavity(ip) respectively, and the MR signal intensity of tumor and liver was determined. Result: In iv group and ip group the maximum enhancement rate of tumor was 70.2% and 46.4% respectively, and there was significant difference. The maximum enhancement rate of liver was 23.7% in ip group and 20.4% in iv group, and there was no signifinant difference. Conclusion: Intravenous injection is in favor of SA-DTPA-Gd’s accumlation in tumor than intraperitoneal injection, and a more homogenious intratumoral distribution is archived.
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Received: 14 September 2005
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2006, Vol. 17 
