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| Relation between renal dynamic imaging and pathological changes in IgA nephropathy |
| GAO Zai-rong, ZHU Hong-yan, ZHANG Jun, LI Zhen-qiong, LIU Jian-she, ZHANG Yong-xue, ZHU Zhong-hua |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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Abstract Objective: To analyze the relation between renal dynamic imaging and pathological changes in IgA nephropathy (IgAN). Methods: Sixty-seven histologically confirmed patients with IgAN were included in this study. According to the extent of renal pathological changes, such as glomerular lesions, tubulo-interstitial lesions and vessel lesions, all patients were divided into several groups according to Katafuchi’s score system and Lee’s histological classification. All of the 67 patients underwent renal dynamic imaging with 99mTc-DTPA (diethylenetriaminepentaacetic acid). And the imaging parameters including perfusion index(PI), glomerular filtration rate(GFR) and 20min clearance(C20) were calculated. The relationship between pathological Katafuchi’s scores and imaging parameters among all Lee’s groups were analyzed. Results: The results indicated that there was a positive correlation between PI and the vessel lesion score (P<0.01), negative correlation between GFR and the glomerular lesion score (P<0.01) and tubulo-interstitial lesion score (P<0.05), and negative correlation between C20 and tubulo-interstitial lesion score (P<0.05). With the Lee’s grade increasing, GFR and C20 gradually decreased, and PI increased. The differences of these imaging parameters among Lee’s groups were significant(P<0.05). Conclusion: The results of renal dynamic imaging closely relate to the renal pathological changes of IgAN, and can better reflect the degree of pathological lesions. Renal dynamic imaging is of practical value in the decision of therapy procedure and evaluation of prognosis of IgAN.
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Received: 22 December 2005
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2006, Vol. 17 
