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| The role of differential diagnosis between radiation necrosis and glioma recurrenceusing multi-modality magnetic resonance imaging |
| ZHANG Xin, ZHANG Bing, LI Ming, WU Wen-bo, WANG Hui-ting, YAN Jing, YANG Yong-bo, LIANG Wei-bang, ZHU Bin |
| The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China |
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Abstract Objective: To investigate the value of DTI, T2*-PWI, 1H-MRS in the differential diagnosis between the glioma recurrence and radiation necrosis. Methods: The imaging features on the above sequences in 15 cases of radiation necrosis and 9 cases of glioma recurrence were studied retrospectively. The nrCBV values, Cho/Cr, NAA/Cr, and Cho/NAA ratios in the enhancing part, peri-local edema, and contralateral normal white matter were measured, and the nerve fiber of the lesions and normal contralateral white matter was reconstructed. Results: The nrCBV values, Cho/Cr and Cho/NAA ratios in the enhancing part and peri-local edema of glioma recurrence were higher than those of radiation necrosis. The sensitivity and specificity of the Cho/Cr ratios in the enhancing part were 93.3% and 100%, and in the peri-local edema, they were 66.7% and 88.9%. The Cho/NAA ratios, in corresponding location, were 86.7% and 100%, 73.3% and 77.8%. There were no statistically differences in the NAA/Cr ratios(P>0.05). Conclusion: The multi-modality magnetic resonance imaging, including DTI, T2*-PWI, 1H-MRS can significantly improve the differential diagnosis between glioma recurrence and radiation necrosis.
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Received: 28 March 2014
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Corresponding Authors:
ZHU Bin
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2014, Vol. 25 
