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| The relationship between 99mTc-MIBI breast cancer imaging andthe expression of multidrug resistance-associated protein and Ki-67 |
| LIN Kai-wen1, LIU Bao-ping2, CHENG Bing2 |
| 1. Department of Nuclear Medicine, Xuchang Central Hospital, Xuchang Henan 461000, China;2. Department of Nuclear Medicine, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China |
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Abstract Objective: To investigate the relationship between 99mTc-MIBI breast imaging results and expression of the drug resistance proteins[multidrug resistance-associated protein(MRP), Ki-67] in human breast cancer tissues. Methods: Thirty-six patients with untreated breast cancer were studied prospectively a week before their surgical operations. They were all injected intravenously with 740MBq 99mTc-MIBI in the arm contralateral to the lesion. Anterior planar images were acquired at 10 and 180 minutes after injection and radioactive washout indices(WI) were calculated. MRP, Ki-67 expression was investigated by immunohistochemical studies on multiple nonconsecutive sections of surgical samples. The differences of the tumor radioactive WI between MRP positive and negative groups, Ki-67 positive and negative groups were compared with. Results: The WI were significantly higher in 13 patients with positive MRP expression when compared with 23 patients with negative MRP expression(16.72±10.17 and 1.76±2.38, P<0.005). However, the differences of WI between the patients with positive and negative Ki-67 expressions were not significant?穴12.47±11.26 and 13.06±12.63, P>0.50). Conclusions: A strong positive correlation was found between the WI of 99mTc-MIBI from the lesions and expression of MRP in untreated breast cancer patients(r=0.783, P<0.001). The WI of 99mTc-MIBI breast imaging may be a useful method for evaluating MRP expression in breast cancer. No significant relationship between 99mTc-MIBI breast imaging results and Ki-67 was found.
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Received: 26 January 2006
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2006, Vol. 17 
