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| MRI evaluation on the treatment of acute cerebral infarction of cat with the combination of bFGF and GbE |
| LIU Huai-jun1, HE Dan1, WU Shuo-chun2, YANG Hua1, FENG Ping-yong1, YAN Li-qun1 |
| 1.Department of Radiology, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China;2.Department of Radiology, Affiliated Children’s Hospital of Capital Pediatric Institute, Beijing 100020, China |
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Abstract Objective: To evaluate the therapeutic effect of bFGF and GbE on acute cerebral infarction with MR imaging. Methods: Forty healthy adult cats were equally and randomly devided into 4 groups. All animals were operated to establish the feline models of cerebral focal ischemia-reperfusion by left transorbital approach. They were injected with sodium chloride intravenously for group A, bFGF for group B, GbE for group C and bFGF+GbE for group D. MR scans performed after operation, included T1WI, T2WI, FLAIR, DWI. Philips’s criteria score were evaluated on the cats. Result: The neurological defects score in group D is remarkably lower than that in group B and C. The lesion on T1WI, T2WI, FLAIR, DWI showed more milder. The area of infarct formation were smaller than that in group B and C through the comparison between the ADC images and T2WI images(T2WI-ADC). Conclusion: The treatment results in group D was better than that in group B and C. Both bFGF and GbE can enhance each other’s therapeutic effects. MR imaging could show the therapeutic effect of bFGF and GbE, especially the T2WI-ADC was an important item to evaluate the therapeutic effects.
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Received: 07 August 2007
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2008, Vol. 19 
