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| Investigation of regional left ventricular function by strain imaging in patients with coronary artery disease |
| QIU Qiong, YANG Li |
| Department of Cardiology, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China |
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Abstract Objective: To quantitatively analyze the characteristics of myocardial motion by strain imaging in ischemic and infarct myocardium in patients with coronary artery disease, in order to explore its clinical value for assessment of regional left ventricular dysfunction. Methods: Twenty-one patients with myocardial infarction, 11 patients with angina pectoris and 20 healthy subjects were studied. Septal, lateral, anterior, inferior, anteroseptal and posterior wall of the left ventricle were scanned respectively using color tissue Doppler imaging, and strain curves were derived. The systolic strain(εsys), the maximum strain(εmax), the postsystolic shortening strain(εpss) and its duration(Tpss) from ischemic, infarct and normal myocardium were measured. The ratios of εpss and εsys, εpss and εmax(εpss/εsys, εpss/εmax) were calculated. Results: Compared with normal myocardium, the absolute magnitude of εsys and εmax were significantly lower, the absolute magnitude of εpss, εpss/εsys, εpss/εmax were significantly larger and Tpss significantly longer in the ischemic and infarct myocardium(all with P<0.01). Compared with the ischemic myocardium, the absolute magnitude of εsys and εmax decreased significantly, εpss/εsys, εpss/εmax and Tpss increased significantly in the infarct one(P<0.01 or P<0.05). Conclusions: Strain imaging can be used to quantitatively analyze regional left ventricular dysfunction in patients with coronary artery disease; postsystolic shortening is a common and important feature of the ischemic and infarct myocardium, εpss/εsys, εpss/εmax and Tpss may aid in differentiating infarct from ischemic myocardium.
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Received: 29 August 2007
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Corresponding Authors:
YANG Li
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2008, Vol. 19 
