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| Correlation study of MRS diagnosis of diffuse axonal injury with clinical prognosis |
| QI Qiang, ZOU Yu-lin, TAO Jin-de, LIU Xiao, LI Zhi-juan, CHEN Zhen-ping, LI Xing-fu, WU Hui-qin |
| Department of Radiology, Dongguan Tung Wah Hospital, Dongguan Guangdong 523110, China |
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Abstract Objective: To study the imaging features of brain diffuse axonal injury(DAI) by magnetic resonance spectroscopy(MRS), and explore the value of MRS in the diagnosis of DAI and severity assessment. Materials and Methods: Thirty patients with DAI(DAI group) and 10 healthy volunteers(control group) undertook 1H-MRS scanning, to assess the metabolite levels of N-acetyl aspartic acid(NAA), choline(Cho), creatine(Cr), combined with Glasgow coma scale(GCS) and Glasgow outcome scale(GOS) score for correlation analysis. Results: Compared with control group, NAA decreased, Cho increased, NAA/Cho, NAA/Cr value decreased and Cho/Cr value increased in DAI group. The change of NAA/Cr, NAA/Cho, Cho/Cr value showed correlation with GCS and GOS in patients with DAI. Conclusion: MRS can quantitatively measure the brain tissue metabolism of patients with DAI, showing important value for the diagnosis and prognosis evaluation of the severity of DAI.
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Received: 16 June 2014
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2014, Vol. 25 
