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| An experimental study of real-time contrast enhanced ultrasound diagnosing hepatic artery stenosis |
| WANG Na, GONG Wei-bing, WU Feng-lin, FANG Xue-jun, CHEN Wei-guo, CHEN Yong |
| Nanfang Hospital, Southern Medical University, Guangzhou 510515, China |
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Abstract Objective: To investigate the feasibility of hepatic artery stenosis with quantitative analyzing of contrast enhanced ultrasound in perfusion of canine liver tissue. Methods: Canine hepatic artery stenosis models were established successfully by thick thread pipe forceps ligature and be validated using X-ray angiography. Sonographic images of liver tissue, abdominal aorta(AO) in front of liver and left ventricle(LV) were captured continuously for a total of 2 minutes after administration of a bolus injection of ultrasound contrast agent(Perfluoropropare-albumin microsphere, 0.025～0.03ml/kg) by femoral vein. Sonographic liver tissue perfusion images were converted into a liver perfusion time-intensity curve(TIC) by the quantitative analyzing software. Furthermore, the respectively calculated parameters such as peak intensity(PI), area under curve(AUC), time to peak(TTP) and Alpha were compared with normal hepatic artery and different stenotic level of hepatic artery, liver tissue, AO and LV. Results: In the hepatic artery stenosis group, they exhibited liver parenchyma intensive level were lower than control group. The PI of liver tissue and the PI ratio of liver tissue/AO or LV were lower than control group（P＜0.05）. In addition, the PI of liver tissue was negatively correlated with hepatic artery stenotic level(r=－0.870, P＜0.001). Conclusions: The PI and PI ratio are most sensitive indices of detect hepatic arterial hemodynamic variation and it can be used to evaluate the stenotic degree of hepatic artery.
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Received: 25 October 2007
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Corresponding Authors:
WU Feng-lin
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2008, Vol. 19 
