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| Study of 3D-magnetic resonance spectroscopy imaging in prostate cancer and benign prostate hyperplasia |
| ZHANG Lin-lin, YUAN Shu-guang, YAN Dong, YANG Fei-fei, DUAN Li-fen, PU Cheng-rong |
| Department of Radiology, the Second Affiliated Hospital of Kunming Medical College, Kunming 650101, China |
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Abstract Objective: To describe MR spectroscopy(MRS) of prostate cancer(PCa), to evaluate MRS in the diagnosis of PCa. Materials and Methods: Clinical data together with MRI and MRS findings were reviewed in 28 cases with pathologically confirmed PCa and 36 cases of benign prostate hyperplasia. MRI observation was focused on the size of the gland, the location of the lesion, the signal features and the extent of the tumor. MRS observation included the chemical shift of citrate(Cit), choline(Cho) and creatine(Cr) spectra, and the ratio of （Cho+Cr）/Cit. Results: On MRI, 22 cases have apparent sign of PCa, in these the affected structures included seminal vesicle(n=18), bladder(n=14), bone of pelvis(n=13), rectum(n=5)and pelvic lymph nodes fused into a mass(n=5). While apparent sign of PCa was not found in 6 cases. On MRS, prostate was divided into six regions and marked the cancer focus into the relative region point on MRS. Six cancer points abstracted from every case, in all of the 64 cases 256 points were selected, Cit peak was obviously declined and Cho peak was high in PCa. The average ratio of (Cho+Cr)/Cit for PCa was 2.3612±1.91178, for benign prostate hyperplasia was 0.6290±0.59067. Conclusion: MRI can display localization of tumor and the detection of extracapsular spread of the disease. MRS can provide the metabolic information the area of PCa and the suspected prostate parenchyma.
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Received: 07 November 2007
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Corresponding Authors:
YUAN Shu-guang
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2008, Vol. 19 
