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| An experimental study of 18F-FDG PET/CT multi-time point imaging for differentiating tumor from inflammation |
| LIU Jun, ZHANG Cai-xia |
| Department of Nuclear Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, China |
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Abstract Objective: To investigate SUVmax and Glut1 for the differentiation of tumor from inflammation using 18F-FDG multi-time point imaging obtained by PET/CT scanner in animal models. Materials and Methods: Tumor group rats were subcutanceously injected wk256 into right oxter, inflammation group rats were intramuscularly injected turpentine into left hind leg. Each animal model was scanned at 20, 40, 60, 80, 100, 120min after FDG injection, SUVmax was measured. HE and immunohistochemistry were analysed for lesions. Results: FDG accumulation of the two groups increased with time, they had a significant difference at 100min(t=2.59, P<0.05); with the early image acquired at 40min, calculated IR40(SUVmax at every time point divided by the SUVmax at 40min), they had a significant difference from 80min(t=3.45, P<0.01). The Glut1 was significantly higher in the tumor(12.67±3.25) than inflammation(7.18±1.52)(P<0.05); The SUVmax of 80min and RI in tumors had positive correlation with Glut1(r1＝0.69, P<0.05; r2＝0.86, P<0.001). The SUVmax of 80min in inflammation had positive correlation with Glut1(r＝0.61, P<0.05), RI had no correlation with Glut1(r＝0.57, P>0.05). Conclusion: The higher Glut1 expression level in the tumor may partially explain the higher FDG accumulation in the tumor than inflammation. FDG of two groups had positive correlation with Glut1, RI was better than SUVmax for differentiating lesions. The proper delayed imaging could shorten the overall testing time rather than single-time-point imaging.
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Received: 18 March 2009
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Corresponding Authors:
ZHANG Cai-xia
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2009, Vol. 20 
