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| An fMRI study for different cognition components of working memory in schizophrenia patients |
| YANG Gui-fen1, ZHANG Quan2, ZHANG Yun-ting2, SHEN Jian-hua3, ZHANG Xin-jun3, CHEN Qing-gang3 |
| 1. Department of Nuclear Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;2. Department of Radiology, General Hospital, Tianjin Medical University, Tianjin 300052, China;3. Andi Hospital of Tianjin City, Tianjin 300052, China |
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Abstract Objective: To investigate the difference of neural mechanism for different cognition components with encoding, maintenance and retrieval process of working memory(WM) between schizophrenia patients and normal subjects using event-related fMRI(ER-fMRI). Methods: Sixteen normal subjects and twenty schizophrenia subjects completed a Sternberg item recognition task using fMRI. Brain activation regions for encoding, maintenance and retrieval process were obtained. Result: Compared to normal subjects, some functional regions associated with encoding, maintenance and retrieval process showed increased activation in schizophrenia patients, i.e. right precuneus for encoding process, left PMA, left DLPFC, right precuneus and left VLPFC for maintaince process, left PMA for retrieval process. In addition, subcortical structures, primary motor cortex and some verbal regions in left temporal lobe also showed more activation. Conclusion: Some functional regions associated with encoding, maintenance and retrieval process showed relatively inefficiency in schizophrenia patients.
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Received: 12 March 2009
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Corresponding Authors:
ZHANG Yun-ting
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2009, Vol. 20 
