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| A correlative study of MSCT enhancement presentation with histo-differentiation and p53 expression in gastric cancer |
| ZHANG Lin, ZHAO Jian-hua, WANG Li-wei, LU Ling-quan, XIE Guang-hui, WU Qian-zhi, YIN Xin-dao |
| Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China |
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Abstract Objective: To investigate the relationship of enhanced MSCT signs of gastric carcinoma to its histological differentiation and expression of p53. Materials and Methods: Total 66 patients of gastric carcinoma were routinely studied preoperatively with dual-phase enhanced CT scan. Routine hematoxylin and immunohistochemical staining of the surgical tumor specimens of all patients was visualized for the histological differentiation and the expression of p53 respectively. The correlation between enhanced MSCT signs of gastric carcinoma and its histological differentiation and expression of p53 were analyzed. Results: The correlation was found between enhanced characteristics of gastric carcinoma and its histological differentiation and expression of p53. Homogenous enhancement showed high/moderate differentiation of adenocarcinoma in 73.1%(19/26). Layered or inhomogenous enhancement showed poorly differentiated adenocarcinoma in 75%(30/40), the difference had statistically significance(P=0.000). Dual-phase enhanced rate had no correlation with histological differentiation of gastric carcinoma(P＞0.05). The positive expression of p53 in layered or inhomogenous enhanced characteristics of gastric carcinoma was significantly different from that in homogenous enhanced characteristics(P＜0.05). The positive expression of p53 was relative to arterial-phased enhanced rate and tumor size and lymph node metastasis of gastric cancer(P＜0.05). Conclusion: Tumor different enhancement and dual-phase enhanced rate reflects various histological differentiation and the positive expression of p53 in gastric carcinoma, which suggests that enhanced MSCT signs of gastric carcinoma are closely correlative to its histological differentiation and expression of p53.
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Received: 17 April 2008
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2008, Vol. 19 
