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| Liver changes demonstrated by B-mode ultrasound in patients with long term treatment of antipsychotics |
| YI Li-fen, ZHU Shao-yi |
| Mental Health Center of Shantou University Medical College, Shantou Guangdong 515063, China |
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Abstract Objective: To study the liver changes in schizophrenic patients treated with long term antipsychotics by B-mode ultrasound. Methods: B-mode ultrasound examination was given to 1255 schizophrenic patients who had used antipsychotics more than 2 years. In the 1255 patients, the first group contained 472 patients who had the treatment for more than 5 years, and the second group contained 783 patients who had the treatment less than 5 years, this group served as the control group. Related items were compared between the two groups. Results: In the first group, intake antipsychotics for more than 5 years, the liver abnormality detected by B-mode ultrasound was 28.05%, among which fatty liver is the most common abnormality, it accounts for 88.09% of all the abnormalities in this group. The change of liver is related to age, course of the disease and the duration of administration of the antipsychotics. The positive rate of liver changes was higher in patients who were more than 50 years old; who had longer course of the disease and who had used medicine 5 years or longer than 5 years, but there were no statistical differences of sex and the type of schizophrenia. Conclusion: B-mode ultrasound can indicate clearly the lesions of liver in patients with long term taken antipsychotics.
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Received: 25 November 2008
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2009, Vol. 20 
