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| Absorbed dose of salivary glands in patients with differentiated thyroid carcinoma receiving 131I ablative therapy |
| LIU Bin, KUANG An-ren, ZENG Yu, PAN Ming-zhi, ZHAO Zhen, WANG Jian-tao |
| Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China |
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Abstract Objective: To estimate the individual absorbed dose to the parotid and submandibular glands in patients with differentiated thyroid carcinoma(DTC) receiving 131I ablative therapy. Methods: Forty patients, including 7 male, 33 female, aged from 17~63(44±15)years, with DTC after thyroidectomy were prospectively recruited in this study. Head-neck anterior and posterior static scintigrams were obtained at 1, 2, 3, 4, 12, 24, 48h after administration of 3.7GBq radioiodine. Manually drawn regions of interest of the parotid and submandibular glands were used to determine the activities arising from salivary glands after background correction. The cumulative activites of salivary glands were computed via area under time-activity curves by Origin 7.0 software. According to MIRD methods, absorbed dose of salivary glands was calculated. Results: The mean absorbed dose to parotid and submandibular gland was (0.15±0.10)mGy/MBq, (0.19±0.07)mGy/MBq, respectively. Conclusion: Radiation dose to the salivary glands of DTC patients receiving 131I abaltive therapy is low.
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Received: 13 November 2008
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2009, Vol. 20 
