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| The characteristics of dynamic contrast-enhanced MR imaging in cervical cancer |
| ZHANG Xian, YAN Zhi-han, YU Zhi-kang, BAI Guang-hui, MAO Chuan-wan |
| Department of Radiology, the 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou Zhejiang 325027, China |
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Abstract Objective: To approach the characteristics of dynamic contrast-enhanced MR imaging in cervical cancer. To provide reference to contrast-enhanced phase choice in cervical cancer. Methods: Twenty-five cases with pathologically proved cervical cancer were served as study group, 4 cases with cervical leiomyoma and 10 volunteers as control group. Plain scan and dynamic contrast-enhanced MR scanning were given to the patients in the study as well as to the individuals in the control group. For imaging data analysis, ROI was selected and time-intensity curves(TIC) were derived from dynamic contrast-enhanced MR imaging of ROI, calculate ROI enhanced rate(E)＝(the post contrast-enhanced signal intensity-the precontrast-enhanced signal intensity)×100%/the precontrast-enhanced signal intensity. On statistics, we compared the differences of enhanced rate respectively at different time, 16s, 32s, 48s, 64s, 128s. The T-test was used, P<0.05 was considered statistically significant. TIC were divided into four types. Results: Almost all cervical cancer showed marked contrast-enhanced appearance in the early period(0~32s). There were significant difference in early enhanced rate between cervical cancer, normal stroma of cervix and leiomyoma(P<0.05), but there were no significant difference on enhanced rate in the intermediate and late phase(P>0.05). In 25 cases with cervical cancer, 22 cases had type Ⅰ curve, 3 cases had type Ⅱ curve. In the control group, almost belong to type Ⅲ and type Ⅳ curve. Conclusion: Dynamic contrast-enhanced MR imaging can reflect the blood supply of the tumor, to emphasize signal change and enhanced rate in the earlier period(0~32s). Dynamic contrast enhanced study is useful to make diagnosis.
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Received: 11 December 2008
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Corresponding Authors:
YAN Zhi-han
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2009, Vol. 20 
