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| Prostate cancer: a comparison study of 1H-MRSI and DWI |
| WANG Xi-zhen1, 2, WANG Bin1, LIU Jin-gang1, NIU Qing-liang3, LIU Zuo-qin2, LIU Qiang2 |
| 1. Medical Imaging Center, Affiliated Hospital of Weifang Medical University, Weifang Shandong 261031, China;2. Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, China;3. Medical Imaging Center, Weifang Traditional Chinese Medicine Hospital, Weifang Shandong 261041, China |
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Abstract To analyze the characteristics of prostate cancer(PCa) in 1H-MRSI and DWI; to explore the relationship between(Cho+Cr)/Cit ratio and ADC value. Materials and Methods: The clinical and pathologic information of 38 patients with histologically proven PCa were studied. MR spectroscopic imaging(MRSI) and diffusion weighted imaging(DWI) were performed using a 1.5T superconductive magnet scanner(Siemens Sonata) with a pelvic phased array multi-coil. MRSI was acquired using CSI-3D-Prostate sequence. All of the data was transferred to Siemens Leonardo Workstation. The (Cho+Cr)/Cit ratio of PCa(n=38), benign prostate hyperplasia(BPH)(n=21) and peripheral zone(PZ)(n=17) were calculated by spectroscopy software. DWI was carried out with a modified single-shot SE echo planar imaging(EPI) sequence. Results: The (Cho+Cr)/Cit ratio of PCa, BPH and PZ was 3.98±0.12, 0.51±0.19 and 0.38±0.09(P<0.05), respectively. The ADC value of PCa, BPH and PZ was (49.32±12.68)×10-5mm2/s, (86.73±26.75)×10-5mm2/s and (126.25±27.21)×10-5mm2/s, respectively. The (Cho+Cr)/Cit ratio and ADC value of PCa was different from that of BPH and PZ(P<0.05). (Cho+Cr)/Cit ratio correlated positively with Gleason grade(r=0.431, P<0.05), while negatively with ADC value(r=-0.309, P<0.05). Conclusion: The metabolite ratios relate closely with tissue microstructure. Combined utility of MRSI and DWI can improve the detection of PCa.
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Received: 07 April 2008
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Corresponding Authors:
WANG Bin
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2008, Vol. 19 
