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| Comparison of the value of CT perfusion, MR perfusion and DWI in the differential diagnosis of malignant liver lesions |
| SHI Li-jing, GUO Yong, LIN Wei, ZHANG Yan-qun, ZHENG Kui-hong, HUANG Min-hua, QIAN Ming-zhu, WANG Jian-he |
| MRI Division, Navy General Hospital, Beijing 100048, China |
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Abstract Objective: To assess and compare the differential diagnostic value of CT perfusion, MR perfusion and DWI in different kinds of malignant liver lesions. Methods: Thirty-nine patients underwent CT perfusion, MR perfusion and DWI scan. They were divided into 3 groups: 15 hepatocellular carcinoma, 11 cholangioma, 13 metastasis tumor. Calculate the ADC value of each case and compare the results of the 3 groups. When CT perfusion and MR perfusion was finished, separate the perfusion curve of liver lesion and hepatic parenchyma into two parts according to the TTP of spleen, calculate the SS of each part, then get the ratio of the two SS, named [SSr(ct)=SSpre/SSpost] to CT perfusion and [SSr(mr)=SSpre/SSpost] to MR perfusion. Then compare SSr(ct) and SSr(mr) of the 3 groups. Results: The ADC value of hepatocellular carcinoma, cholangioma and metastasis tumor was (1.04±0.13)×10-3mm2/s, (1.33±0.27)×10-3mm2/s, and (1.11±0.19)×10-3mm2/s, respectively. The results of cholangioma were significantly higher than hepatocellular carcinoma and metastatic tumor(P<0.05), but the difference between hepatocellular carcinoma and metastatic tumor was not significant(P=0.424). The SSr(ct) and SSr(mr) of the 3 groups were: 2.46±0.34 and 3.09±0.77, 1.03±0.21 and 1.12±0.21, 0.94±0.29 and 0.99±0.37. The results of metastatic tumor was significantly lower than those of hepatocellular carcinoma(P<0.05), either of the difference between hepatocellular carcinoma or cholangioma(P<0.05). The difference between metastatic tumor and cholangioma was not significant(P>0.05). Conclusion: To the differential diagnosis of hepatocellular carcinoma and metastasis tumor from cholangioma, DWI has advantage than CT perfusion and MR perfusion. While the perfusion evaluation of CT and MR has more advantage in the diagnosis of hepatocellular carcinoma and metastatic tumor.
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Received: 31 July 2009
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2010, Vol. 21 
