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| Application of FA and ADC values in AIDS patients with brain opportunistic infection:a comparative study of tuberculosis and toxoplasmosis |
| CHU Xiang-le, ZHAO Li-ping, MA Jing-xu, WANG Yun-ling, WANG Hong |
| Department of Radiology, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China |
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Abstract Objective: To study the clinical application of FA and ADC values in brain AIDS-associated infection. Methods: 22 subjects who suffered from AIDS(12 brain tuberculosis and 10 toxoplasmosis) were recruited to perfprm routine MRI, T1WI-CE and DTI sequences. Morphological characteristics of lesions were observed. ADC and FA values of the lesional solid areas, edematous areas and the contralateral normal areas were measured. The diagnostic efficiency of the two values were analyzed by ROC curve. Results: Significant differences of ADC and FA values were observed among the three regions between subjects with brain tuberculosis and those with toxoplasmosis(P<0.05). Compared with the contralateral normal areas, ADC and FA values of the solid areas and edematous areas in two groups showed significant differences(P<0.05). For lesional solid and edematous areas, FA values and ADC values in the the groups showed significant differences. FA values of the solid area in two groups showed significant difference(P<0.05). ROC curves showed the AUC of FA value was larger than that of ADC value(0.932 vs 0.715, respectively, P<0.05). Conclusion: DTI helps to diagnose brain tuberculosis or toxoplasmosis in AIDS patients and provides evidences for medical treatment.
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Received: 29 October 2014
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2015, Vol. 26 
