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| Correlation between ultrasonography features and expression of Ki67 and p53 in breast cancer and its clinical significance |
| LI Hong1, LI De-hua1, HU Bo2 |
| 1.Liaoning Medical University, Jinzhou Liaoning 121001, China;2.The Fourth Hospital of Fushun, Fushun Liaoning 113000, China |
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Abstract Objective: To investigate the expression of Ki67 and p53 in breast cancer, and their correlation with color Doppler ultrasound features. Methods: 135 cases of breast cancer confirmed by pathology were retrospectively enrolled for the color Doppler ultrasound features, including tumor size, edge, shape, distribution and morphology of calcification, flowing image grading, lymph node metastasis and surrounding tissues invasion. The expression of Ki67 and p53 was detected with immunohistochemical methods and their correlations with color Doppler ultrasound features were analyzed. Results: The positive rate of Ki67 and p53 in breast cancer tissue were 64.4%(87/135) and 51.1%(69/135) respectively. The expression of Ki67 and p53 showed no correlation with tumor size and tumor edge(P>0.05), but correlated significantly with flowing image grading, lymph node metastasis and surrounding tissues invasion(P<0.05). The expression of Ki67 had significant correlations with tumor morphology and calcification(P<0.05), but no correlation with the distribution of calcification(P>0.05). The expression of p53 had no correlation with tumor morphology and shape of calcification(P>0.05), but significant correlation with the distribution of calcification(P<0.05). The expressions of Ki67 and p53 were positively correlated(r=0.617, P<0.05). Conclusion: There were correlations between ultrasound features and expression of Ki67 and p53 in breast cancer. Color Doppler ultrasound features may play a potential role in clinical application of non-surgical treatment and presurgical assessment of breast cancer.
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Received: 19 November 2014
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2015, Vol. 26 
