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| Correlation study of CT features, pathology and the serum CEA concentration in peripheral lung cancer |
| TAN Li-lian, ZHOU Jie, LI Zhi-ming, JIANG Jin-dai, LI Shu-xin, ZHANG Wan-hong |
| CT Division, the Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China |
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Abstract Objective: To discuss the correlation of pathology, CT features and serum CEA concentration in peripheral lung cancer. Materials and Methods: The pathology, CT features and the serum CEA concentration in 48 cases of peripheral lung cancer, confirmed by operation and pathology, were analyzed. Results: The serum CEA concentration was (13.23±20.47)ng/ml(adenocarcinoma, n=30), (3.62±2.48)ng/ml(squamous carcinoma, n=11). There was no correlation between the serum CEA concentration and the tumor differentiation degree in lung cancer(r=-0.017). The serum CEA concentration were higher in lung cancer with deep lobulation sign or diameter≥3cm. There was no significant difference between lung cancer with pleural indentation sign, spiculation sign, increased CT value≥20HU after enhancement, calcification or enlargement of hilar or mediastinal lymph nodes and serum CEA concentration. There was positive correlation between the percentage of Ki-67 antigen and the serum CEA concentration in lung cancer(r=0.576). The serum CEA concentration was (19.37±24.40)ng/ml(p53 positive group), (3.64±2.11)ng/ml(p53 negative group). Conclusion: There was positive correlation between serum CEA concentration, the percentage of Ki-67 antigen, expression of p53, deep lobulation sign and diameter≥3cm of peripheral lung cancer. There was no significant difference between tumor differentiation degree and serum CEA concentration in peripheral lung cancer.
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Received: 22 October 2010
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2011, Vol. 22 
