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| The clinical study of differentiating benign and malignant breast tumors by diffused optical imaging with ultrasound |
| YOU Jun, XIANG Fei-xiang, XIE Ming-xing, YAN Tian-wei, QIN Xiao-juan, XIE Man-ying |
| Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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Abstract Objective: To assess the diagnostic value of diffused optical imaging with ultrasound(OPTIMUS) in differentiating benign and malignant breast tumors and the correlation between the quantitative parameters from the report of OPTIMUS and pathological results. Methods: We selected 52 patients with suspected malignant breast tumors by ultrasound(excluding those with typical cysts and fibroadenomas) in Wuhan Union Hospital from April to May of 2011. The breast tumors of the patients were examined by OPTIMUS. The diagnostic accuracy of the OPTIMUS and the correlation between the quantitative parameters and pathological results were analyzed by comparing the reports and pathological results. Results: Forty-five patients had accepted surgery treatments before November 2011. OPTIMUS reported 23 tumors with BI-RADS 1~3 and 22 tumors with BI-RADS 4~5, and pathological results showed that 26 tumors were benign and 19 tumors were malignant. The sensitivity, specificity, positive predictive value, negative predictive value of the diagnosis of OPTIMUS were 89.5%(17/19), 80.8%(21/26), 77.3%(17/22), 91.3%(21/23), respectively. There were significant differences in the comprehensive diagnostic parameters(P=0.000), total hemoglobin(P=0.025), tumor direction(P=0.009), shape factor(P=0.001) between benign and malignant tumors. In sub-parameters, total hemoglobin and tumor direction entered the Logistic regression equation, and total hemoglobin(standardized regression coefficient 2.817) was more relevant to tumor direction(standardized regression coefficient 1.180). Conclution: OPTIMUS has effective identification of benign and malignant breast tumors. Total hemoglobin, as a new quantitative parameter, is directly related to the nature of tumor pathology, and some sub-parameters are related to the nature of tumor pathology. OPTIMUS provides quantitative information for clinical diagnosis.
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Received: 14 February 2012
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Corresponding Authors:
XIANG Fei-xiang
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2012, Vol. 23 
