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| The value of contrast-enhanced ultrasound in raising the accuracy of biopsy for multiple liver occupying lesions |
| SUN Yi-xin, CHENG Wen, YANG Hong-yan, WANG Qiu-cheng, GUO Dan-yang, ZHANG Dan-dan |
| Department of Ultrasound, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China |
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Abstract Objective: To evaluate the clinical utility of contrast-enhanced ultrasound(CEUS) in percutaneous liver biopsy of multiple liver lesions. Methods: One hundred and twenty-eight patients with multiple unidentified occupying lesions in liver were randomly divided into two groups: CEUS group in which 62 cases underwent liver biopsy directed by real time grey CEUS, and routine ultrasound(US) group in which 66 patients underwent biopsy guided by conventional ultrasonography. There were 86 males and 42 females, mean aged 53.2(36~74). There was no significant difference in the size of lesions between the two groups. 18 gauge needles were used in biopsy, and then biopsy specimens were sent to pathology department for histological and cytological examination. Acquirement of adequate quantity of specimen for pathological examination meant successful biopsy. Results: The proportion of no more than 2 puncture successful in the CEUS group was significantly higher than that in the US group(P=0.000 2). The accurate diagnosis rate of the CEUS group was 94.7%, significantly higher than that of the US group(84.36%, P=0.029). The accurate diagnosis rate of small malignant lesions in the CEUS group was 96.6%, significantly higher than that in the US group(82.1%). No major complication occurred. Conclusion: Biopsy guided by CEUS is more accurate in diagnosis of malignant nodes and hyperplasia nodes in cirrhosis of liver by the reflection of the blood perfusion of lesions, and can determine the area of activity or the necrosis of malignant tumors accurately. It increased the success rate of biopsy and confirmed diagnosis rate of malignant lesions.
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Received: 16 October 2012
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2013, Vol. 24 
