Abstract Objective: To probe the clinical value of quantitative analysis of contrast-enhanced ultrasound on diabetic nephropathy(DN). Methods: Eight patients of clinical definite stage Ⅲ and Ⅳ DN were selected as early period group and clinical period group respectively, meanwhile 8 healthy volunteers with age, height, weight matched were included as control group． We observed the quantitative perfusion parameters of time-intensity curve(TIC) on QLAB quantitative analysis software, and the statistical differences among the three groups. Results: Compared with control group, the area under curve(AUC) increased and the derived peak intensity(DPI) of renal cortical perfusion reduced in the early period group(P<0.05). Compared with control group, the time to peak(TTP) prolonged, the DPI reduced, the AUC reduced and the slope rate of ascending curve(A) of renal cortical perfusion increased in clinical period group(P<0.05). There was no statistical difference of the slope rate of descending curve(a) among the three groups. Conclusion: Quantitative analysis with contrast-enhanced ultrasound can evaluate DN early, sensitively and conveniently.
2013, Vol. 24 
