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| The application of MR diffusion-weighted image in the evaluation of early therapeutic effect of local thermal ablation for hepatocellular carcinoma |
| PAN Jing-jing1, YU Jie2, ZHONG Yan2, TANG Ye-huan2, YE Hui-yi2 |
| 1. Department of Radiology, Second Artillery General Hospital, Beijing 100088, China; 2. General Hospital of PLA, Beijing 100853, China |
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Abstract Objective: To investigate the application of MR diffusion-weighted image(DWI) in evaluating the early therapeutic effect of local thermal ablation for hepatocellular carcinoma(HCC). Methods: Twenty-one nodules histologically proved HCC in 21 patients were enrolled. All patients received DWI with different b values before and immediately after(within 24 hours) local thermal ablation. The differences of ADC values with the same b values between pre- and post-ablation were measured. Receiver operating characteristic(ROC) curve analysis was performed for the comparison of viable tumor and necrostic tissue. Results: The ADC value post-ablation increased significantly than pre-ablation of each b value(P＜0.01). The ADC value was an effective parameter for identifying necrotic tissue: when b value was 1 000 s/mm2, a threshold value of 1.09× 10-3 mm2/s permitted 89.5% sensitivity and 63.2% specificity and a threshold value of 1.26×10-3 mm2/s permitted 52.6% sensitivity and 89.5% specificity. Conclusion: DWI has the capacity of evaluating early therapeutic effect of thermal ablation for HCC.
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Received: 09 June 2013
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Corresponding Authors:
YE Hui-yi
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2013, Vol. 24 
