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| Application of MSCT perfusion scanning and the correlation between CT perfusion parameters and tumor factors in gastric tumors |
| HUANG Gang, WANG Li-li, XU Xiang-jiu, MAO Ze-qing, ZHAO Xue-mei |
| Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China |
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Abstract Objective: To explore the value of perfusion CT in the diagnosis of gastric tumors, and assess the relationship between perfusion imaging parameters and tumor factors of gastric cancer. Methods: All cases were divided into stomach cancer group and normal group. The data of CTPI(BF, BV, MTT, PS) in gastric cancer and normal gastric wall were compared the study index was analysed by independent-samples t test． Pearson correlation were used to analyse the relationship between gastric cancer and tumor factors. Judge diagnostic validity of perfusion parameters on gastric cancer with ROC curve. Results: The level of PS in patient with gastric cancer was significantly higher than that of normal patients. The difference was statistically significantly(P<0.01). The difference of BF between the two groups was statistically significant(P<0.05). The level of BV, MTT showed no significant difference between stomach cancer and normal group(P>0.05). Pearson correlation analysis showed PS had significant correlation with AFP, CEA, CA199, CA72-4(r=0.58, 0.40, 0.38, 0.77, respectively）. But BV, BF, MTT had no correlation with CEA, AFP, CA199, CA72-4. ROC curve were applied to BV, BF, MTT and PS in gastric cancer, the area under the curve were 0.62, 0.64, 0.50, 0.83 respectively. With an area under the ROC curve of PS=18.85 mL/(min·100 g) as the diagnostic critical point. The sensitivity and specificity were 0.88 and 0.67 respectively. Conclusion: MSCTPI can provide hemodynamics of gastric tumors, thus playing a role in the diagnosis of gastric tumors, PS has the most important diagnostic significance. Some perfusion parameters had significant correlation with tumor marks.
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Received: 25 April 2013
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Corresponding Authors:
XU Xiang-jiu
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2013, Vol. 24 
