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| Value of strain ratio in the tiny solid breast masses |
| SHEN Xi-lin, LONG Chun-yan, LU Li-ping, MO Chun-sheng, WANG Kun, CAO Xiu-huai, LIU Wen-hui |
| The Affiliated Nanhai Hospital, Nanfang University of Medical Science, Foshan Guangdong 528200, China |
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Abstract Objective: To evaluate the diagnostic value of strain ratio(SR) in the differential diagnosis of benign and malignant minimal solid breast masses(the largest diameter ≤10 mm) masses. Methods: By analyzing 184 breast lesions in real-time ultrasound elastography images. Calculated the mean SR of each lesion with the surrounding tissues, pathological result was used as the diagnostic standard, receiver operating characteristic(ROC) curve was used for statistical analysis to determine the optimal diagnostic threshold fo benign and malignant breast lesions. Results: The average SR of benign lesions was significantly lower than that of malignant ones (1.81±0.334) vs (2.92±0.753). According to the ROC curve, the area under the ROC curve was 0.891, the area of the standard error was 0.023 and area of the 95% confidence inteval(0.846~0.935), not including 0.5, P=0.000. There was significant difference. The best cut-off point for SR was 2.165. Its corresponding sensitivity(Se), specificity(Sp) was 81.4% and 77.2% respectively. The Youden index（YI） was 0.586. The Se and Sp was maximum (1.586) and the missed diagnosis and misdiagnosis rate was minimal(0.414). Conclusions: SR analysis is useful for the diagnosis of benign and malignant tiny solid breast masses.
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Received: 10 July 2013
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2013, Vol. 24 
