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| The effect of ROI size of the vertebral lesion on DWI in the differentiation between benign and malignant lesion by influencing ADC value |
| WU Bin, JIN Biao, YIN Sheng-li |
| Department of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Chongming Branch, Shanghai 202150, China |
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Abstract Objective: To explore whether there is any effect of the size of region of interest(ROI) on diffusion weighted imaging(DWI) of the vertebral lesions on the measurement of ADC value, thus influencing the differential diagnosis between benign and malignant lesions. Methods: Sixty patients with 92 benign or malignant lesions of the vertebral body confirmed by clinical followed up and long term radiographic review were collected and analyzed. Conventional MRI and DWI were performed on each patient. Two different sizes of ROIs were placed on the center of the lesion in each patient. The signal intensity of the lesion and ADC value were measured and statistically analyzed. Results: The ADC value of different ROI sizes on the same lesion had statistical significance(P<0.05). Moreover, the mean ADC value of smaller ROI size was higher than that of bigger size ROI. The mean ADC value in benign and malignant vertebral lesions in a small ROI or in a large ROI had statistical significance(P<0.05). Conclusion: It is concluded that the size of ROI could affect ADC value in vertebral lesions, and further affect the differential diagnosis between benign and malignant vertebral lesions.
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Received: 25 April 2013
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2013, Vol. 24 
