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| Clinical prognosis of isolated absence of septum pellucidum diagnosed with prenatal ultrasonography |
| ZHANG Bo, YANG Tai-zhu, ZHU Qi, LUO Hong |
| Department of Ultrasound, West China Second Hospital, Sichuan University, Chengdu 610041, China |
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Abstract Objective: To evaluate the clinical characteristics and the corresponding outcome of fetuses with isolated absence of septum pellucidum(ASP) diagnosed by prenatal ultrasonography. Methods: Clinical data of 14 fetuses with isolated ASP diagnosed in our hospital were from January 2009 to December 2012 analyzed retrospectively. Postnatal follow-up was also conducted, and children’s nervous system development was emphatically observed. Results: Totally 14 ASP fetuses were born and successfully followed up, 12 had normal neurological examinations, 2 got nervous system developmental retardation(one had language deficit and behavioral problem, the other one diagnosed as septo-optic dysplasia and language development delay). Five fetuses underwent MRI examination, of which 4 had normal optic chiasma and optic track, one was difficult to assess. Conclusion: Ultrasonography is an effective method for prenatal identification of ASP. MRI serves to confirm the sonographic findings as well as offering additional diagnostic information. These lesions, when isolated, may be associated with a favorable outcome, however, postnatal follow-up should be strongly emphasized, especially the assessment of neuropsychological and psychiatric development of children with isolated ASP.
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Received: 22 July 2013
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Corresponding Authors:
LUO Hong
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2013, Vol. 24 
