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| Tract-based spatial statistics analysis of white matter changes in subjects with subjective cognitive decline |
1. Xuanwu Hospital of Capital Medical University, Beijing 100053, China;
2. School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai Shandong 264209, China;
3. Key Laboratory of Molecular Imaging, Chinese Academy of Sciences, Beijing 100190, China |
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Abstract Objective: To analyze the magnetic resonance diffusion tensor imaging(MR-DTI) datas in patients with subjective cognitive decline(SCD) using tract based spatial statistics(TBSS), to observe brain structural changes in the SCD phase. Methods: Twenty-seven SCD subjects and 37 age-, sex- and education-matched normal controls(NC) were employed in this study. Whole-brain diffusion tensor imaging(DTI) and a battery of neuropsychological tests, including mini-mental state examination(MMSE), montreal cognitive assessment(MoCA) and auditory verbal learning test(AVLT), were acquired on every subject. To figure out the white matter impairments regions of SCD, we conducted two sample t-test between SCD and NC by tract-based spatial statistics(TBSS) analysis on fractional anisotropy(FA) maps. Mean and max values of FA in the regions of white matter impairments were also obtained to investigate the relationship with the neuropsychological tests scores. Mean diffusivity(MD), radial diffusivity(RD) and axial diffusivity were analyzed in the similar manner. Results: Compared with NC, the SCD group showed decreased FA and increased MD and RD and unchanged AxD in corpus callosum, bilateral corona radiata, inferior longitudinal fasciculus, superior longitudinal fasciculus, internal capsule, superior fronto-occipital fasciculus, inferior fronto-occipital fasciculus, external capsule, fornix, and right cingulate gyrus, thalamic radiation, and left uncinate fasciculus. MD values were significantly negatively correlated with AVLT learning and delayed recall(P<0.05). RD values were negatively correlated with AVLT delayed recall(P<0.05). FA, MD and RD were not markedly correlated with MMSE and MoCA. Conclusions: Extensive white matter(WM) damage were observed in SCD. In addition, the MD, RD values were associated with memory function. It might indicated that the SCD subjects had suffered from the pathological changes, while the pathological changes were unable detected by conventional objective neuropsychological tests.
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Received: 28 May 2015
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