|
|
|
| Quantitative analysis of aging changes of human submandibular glands using magnetic resonance imaging |
1. Department of Radiology, Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou Jiangsu 215002, China;
2. The Second Affiliated Hospital of Soochow University, Suzhou Jiangsu 215004, China |
|
|
|
|
Abstract Objective: To explore the age-related characteristics of volumes, T1WI, T2WI, and contrast T1WI signal intensities(SI) and apparent diffusion coefficients(ADC) of submandibular glands. Methods: Three hundred subjects with normal submandibular glands were divided into four different age groups and examined with a 1.5T MR unit. T1WI, T2WI, contrast T1WI and diffusion-weighted MR images(DW MRI) were obtained, and bilateral submandibular glands were segmented manually. Relative signal intensities(RSI) of T1WI, T2WI and enhanced-T1WI and value of ADC were calculated. Results: There was no significance in volumes of submandibular between four different age groups(P＞0.05). The ADC of submandibular glands showed a significant difference between the minority and middle age group(P＜0.01). The mean submandibular gland volume was higher in males demonstrating a significant difference between genders(t=4.576, P＜0.01). No significant differences was observed in all parameters of CSF among four groups(P＞0.05). There also was no significant difference between right and left glands in all parameters(P＞0.05). Conclusion: Quantitative evaluation of MRI on aging morphological and functional changes of submandibular glands can provide baseline references for salivary glands aging research and differential diagnosis of submandibular gland diseases.
|
|
Received: 23 May 2015
|
|
|
|
Corresponding Authors:
XU Liang
|
|
|
|
[1]Saito N, Sakai O, Bauer CM, et al. Age-related relaxo-volumetric quantitative magnetic resonance imaging of the major salivary glands[J]. J Comput Assist Tomogr, 2013, 37(2): 272-278.
[2]Mahne A, El-Haddad G, Alavi A, et al. Assessment of age-related morphological and functional changes of selected structures of the head and neck by computed tomography, magnetic resonance imaging, and positron emission tomography[J]. Semin Nucl Med, 2007, 37(2): 88-102.
[3]Yoshino N, Yamada I, Ohbayashi N, et al. Salivary glands and lesions: evaluation of apparent diffusion coefficients with split-echo diffusion-weighted MR imaging-initial results[J]. Radiology, 2001, 221(3): 837-842.
[4]Kaneda T, Minami M, Ozawa K, et al. MR of the submandibular gland: normal and pathologic states[J]. Am J Neuroradiol, 1996, 17(8): 1575-1581.
[5]许洪敏, 嵇鸣. 干燥综合征的腮腺3.0T MR检查[J]. 中国临床医学影像杂志，2014，25（5）：318-320.
[6]Scott J. Quantitative age changes in the histological structure of human submandibular salivary glands[J]. Arch Oral Biol, 1977, 22(3): 221-227.
[7]董绍忠，吴奇光，郑麟蕃. 人颌下腺年龄变化的定量组织学研究[J]. 中华口腔医学杂志，1989，24（1）：15-17.
[8]Kurashima C, Hirokawa K. Age-related increase of focal lymphocytic infiltration in the human submandibular glands[J]. J Oral Pathol, 1986, 15(3): 172-178.
[9]Smith CH, Boland B, Daureeawoo Y, et al. Effect of aging on stimulated salivary flow in adults[J]. J Am Geriatr Soc, 2013, 61(5): 805-808.
[10]Yonetsu K, Yuasa K, Kanda S. Quantitative analysis of the submandibular gland using computed tomography[J]. Dentomaxillofac Radiol, 1996, 25(2): 97-102.
[11]柳晓冰，俞光岩，唐广健，等. 人类大涎腺CT值的增龄性改变[J]. 中华口腔医学杂志，1999，34（2）：73-75.
[12]Watannbe S, Dawes C. Salivary flow rates and salivary film thickness in five-year-old children[J]. J Dent Res, 1990, 69(5): 1150-1153.
[13]Nagler RM. Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring[J]. Biogerontology, 2004, 5(4): 223-233.
[14]Ono K, Morimoto Y, Inoue H, et al. Relationship of the unstimulated whole saliva flow rate and salivary gland size estimated by magnetic resonance image in healthy young humans[J]. Arch Oral Biol, 2006, 51(4): 345-349.
[15]Boyd ZT, Goud AR, Lowe LH, et al. Pediatric salivary gland imaging[J]. Pediatr Radiol, 2009, 39(7): 710-722. |
|
|
|
