与人脑白质磁共振弛豫时间近似的琼脂凝胶模型制备的实验研究

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Abstract Objective: To set up an MR study model for an appropriate mix ratio of agar and gadoteric acid similar to the relaxation time of white matter of adult brain. The mixture is expected to be a substitution of adult brain in MRI experiment. Methods: After a phantom was made of 0.03 mmol/L, 0.06 mmol/L, 0.09 mmol/L, 0.2 mmol/L, 0.4 mmol/L, 0.6 mmol/L, 0.8 mmol/L gadoteric acid mixed with 1%(g/dl) and 1.5%(g/dl) agar respectively, it was fixed around adult brains(n=11) to be scanned by a 1.5T superconducting unit to get T1 and T2 maps. Then the curve equations were fitted by regression analysis of T1, T2 values of every mixture. Single goal seeking was used to calculate the ranges of mix ratio matching to the relaxation times of 95% CI(means) of brain white matter. According to the calculated mix ratio, another phantom was made to compare it’s relaxation times to the white matter. Results: The 95% CIs(means) of T1 and T2 of white matter were 792.14~848.59(820.36) ms and 83.45~86.09(84.77) ms, respectively. The calculated mix ratio matching to the 95% CI(means) of T1 of white matter as follow: 0.10~0.11 mmol/L(0.11 mmol/L) gadoteric acid mixed with 1% agar, 0.09~0.10 mmol/L(0.10 mmol/L) gadoteric acid mixed with 1.5% agar. The calculated mix ratio matching to the 95% CI(means) of T2 of white matter as follow: 0.49~0.56 mmol/L(0.52 mmol/L) gadoteric acid mixed with 1% agar, 0.08~0.12 mmol/L(0.10 mmol/L) gadoteric acid mixed with 1.5% agar. Conclusion: A range of 0.09~0.10 mmol/L gadoteric acid mixed with 1.5% agar is an appropriate mix ratio matching to the both T1 and T2 value of adult brain white matter, which can provide an analog MRI signal of human white matter.

Key words： Brain Gels Magnetic resonance imaging

PACS:	Ｒ338.2
	Ｒ445.2

Corresponding Authors: GONG Xiang-yang

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	Articles by authors
	GE Zu-feng1
	GONG Xiang-yang2
	ZHU Li-li1
	ZHU Shi-qiang1
	WU Wei1
	SHAN Deng-feng1

Cite this article:

GE Zu-feng1,GONG Xiang-yang2,ZHU Li-li1, et al. A model for an appropriate mix ratio of agar and gadoteric acid similar to the relaxation time of#br# white matter of human brain: experiment study[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(3): 157-160.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I3/157

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