精神分裂症患者顶下小叶亚区水平灰质体积损害分析

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Abstract Objective: To explore subregional-level grey matter volume(GMV) impairments in the inferior parietal lobule(IPL) in schizophrenia and their clinical correlations. Methods: MRI structural images were obtained from 95 schizophrenia patients and 104 sex- and age-matched healthy subjects. Based on a previous parcellation study, the IPL was divided into 11 subregions. The GMV of each subregion was calculated for each subject and was compared between the two groups using general linear model after controlling for the effects of sex and age. Spearman’s correlation coefficients were calculated between the GMVs of the IPL subregions with significant intergroup differences and the clinical parameters. Results: Compared with healthy subjects, schizophrenia patients showed significant GMV reduction in all the 5 anterior subregions and in only 1 middle and posterior subregion of the IPL. The GMV of the left PFt showed negative correlation with the duration of the illness(r=-0.212, P=0.042) and the GMV of the right PF+PFt was positively correlated with the PANSS positive score(r=0.231, P=0.027). Conclusion: The anterior subregions are the main portion of the IPL that exhibits structural impairments in schizophrenia.

Key words： Schizophrenia Magnetic resonance imaging

Received: 02 February 2016

PACS:	Ｒ749.3
	Ｒ445.2

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	Articles by authors
	LIU Xing-yun
	XU Yong-jie
	XU Li-xue
	YU Chun-shui

Cite this article:

LIU Xing-yun,XU Yong-jie,XU Li-xue, et al. Subregional-level grey matter volume impairments in the inferior parietal lobule in schizophrenia[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(4): 229-231.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I4/229

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