肝脏特异性对比剂Gd-EOB-DTPA增强磁共振在肝细胞癌诊断中的价值——Meta分析

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Abstract Objective: To systematically assess the diagnostic performance of Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma(HCC) using a Meta analysis. Methods: The literatures about the Gd-EOB-DTPA enhanced MRI in the diagnosis of HCC taking the pathology or comprehensive results of clinic data, laboraotory examination, imageological examination and follow-up as a gold standard were got by researching the library database of Pubmed, Ovid, EBSCO, Cochrane library, Wanfang database, Weipu database and CNKI. The criteria were established based on validity criteria for diagnostic research published by the cochrane methods. The methodological quality of the included literatures was assessed and data were extracted. Statistical analysis was performed by using the Meta Disc 1.4 software. Heterogeneity of the included literatures was tested, which was used to select proper effect model to calculate the sensitivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR) and diagnostic odds ratio(DOR). Then, the summary receiver operating characteristic curve(SROC) was got, and the area under curve(AUC) was calculated. Sensitivity analysis was carried on. Results: Totally 20 studies met the inclusion criteria. No significant threshold effect but heterogeneity was found in these studies. Using random effect model for meta-analysis, the sensitivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR), diagnostic odds ratio(DOR) and their 95%CI were 0.87(95%CI 0.85~0.89), 0.94(95%CI 0.92~0.95), 10.69(95%CI 5.81~19.67), 0.11(95%CI 0.07~0.19) and 111.77(95%CI 53.71~232.60), respectively. AUC was 0.965 and Q index was 0.911. The sensitivity analysis demonstrated that the stability of included literatures was good. Conclusion: Liver-special contrast agent Gd-EOB-DTPA enhanced MRI can be regarded as an effective and feasible method for diagnosis of HCC, with higher sensitivity and specificity, providing important basis for clinic therapy.

Key words： Carcinoma, hepatocellular Pentetic acid Meta-analysis Magnetic resonance imaging

Received: 28 March 2016

PACS:	Ｒ735.7
	Ｒ445.2

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	Articles by authors
	SHI Hua-liang
	MAO Ming-wei
	LIANG Chang-yu

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SHI Hua-liang,MAO Ming-wei,LIANG Chang-yu. Liver-specific contrast agent Gd-EOB-DTPA enhanced MRI in the diagnosis of hepatocellular carcinoma: a Meta analysis[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(12): 875-880.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I12/875

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