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| Preliminary study of cerebellar magnetic resonance spectroscopy on simple febrile convulsion in children |
| ZOU Jing, XU Ai-hua |
| Yantai Affiliated Hospital of Binzhou Medical University, Yantai Shandong 264100, China |
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Abstract Objective: To explore changes in metabolite levels of cerebellum for children with simple febrile convulsion (SFC) by magnetic resonance spectroscopy(MRS). Methods: Nine children diagnosed SFC and seven age-matched healthy children were enrolled. Multi-voxel chemical shift imaging was performed. The metabolite ratios of cerebellum involving NAA/Cr, NAA/Cr2, Cho/Cr, Cho/Cr2 and NAA/Cho were estimated. The Mann-Whitney U test was performed to compare the differences between the two groups. Lac peak was recorded and analysed between two groups and Fisher’s exact test was performed to compare the differences. Results: The ratio of NAA/Cr in cerebellum with SFC was found to be decreased compared to normal control subjects(0.91±0.12 vs 1.03±0.07, P=0.023). There was no statistical difference for the ratios of NAA/Cr2, Cho/Cr2, NAA/Cho(P>0.05). Lac peaks were detected in the cerebellum of five cases with SFC and no Lac peak was detected in the control group. The difference showed statistical significance(P=0.034). Conclusion: MRS is a useful tool for evaluating major changes in metabolite levels of brain and may contribute to evaluate the damage caused by SFC from the biochemical aspect.
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Received: 25 March 2016
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2017, Vol. 28 
