单、双指数模型扩散加权成像鉴别诊断肝脏富血供病变良恶性的价值

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Abstract Objective: To investigate the value of monoexponential and biexponential model diffusion-weighted imaging in differentiating benign and malignant hepatic hypervascular lesions. Materials and Methods: Forty-four patients(48 lesions) with pathologically or clinically confirmed hepatic hypervascular lesions, were analyzed retrospectively and categorized into benign and malignant groups. All patients underwent routine MR scan and parallel multi b value DWI(b=0, 50, 100, 150, 200, 400, 600, 800, 1 000, 1 200 s/mm2) to obtain the monoexponential modeling value ADC(b=0, 800 s/mm2) and IVIM parameters of biexponential modeling: fast diffusion coefficient Dfast value, slow diffusion coefficient Dslow value and fast diffusion component percentage of F value. Independent two-samples t test was used to compare ADC value, Dfast value, Dslow value and F value between hypervascular benign and malignant groups. Receiver operating characteristic(ROC) curve was used to evaluate those parameters in differentiating benign and malignant lesions and identifying hyper- or hypovascular. Results: The ADC, Dslow value of benign group((1.75±0.68)×10-3 mm2/s, (1.61±0.39)×10-3 mm2/s) were statistically higher than those of malignant group((1.21±0.21)×10-3 mm2/s, (0.99±0.19)×10-3 mm2/s). The Dfast and F values of benign group((30.93±20.00)×10-3 mm2/s, (34.01±11.48)%) were higher than those of malignant group((28.56±18.56)×10-3 mm2/s, (31.37±9.86)%) with no statistical significance. The sensitivity, specificity, accuracy and the area under ROC in differentiating benign and malignant hypervascular lesions were 80.76%, 86.36%, 83.33%, 0.875; 92.30%, 95.45%, 95.83%, 0.945; 46.12%, 72.72%, 60.87%, 0.534, 53.84%, 68.18%, 60.41%, 0.545 by using a threshold ADC, Dslow, Dfast, F values of 1.35×10-3 mm2/s, 1.25×10-3 mm2/s, 20.61×10-3 mm2/s, 32.36% respectively. Conclusion: The ADC value obtained with monoexponential modeling and Dslow obtained with biexponential modeling are useful in differentiating benign and malignant hepatic hypervascular lesions, and Dslow has the highest diagnostic efficacy.

Key words： Liver neoplasms Liver diseases Diffusion magnetic resonance imaging

Received: 19 April 2016

PACS:	Ｒ735.7
	Ｒ445.2

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	Articles by authors
	YING Ming-liang
	SHU Jin-er
	PAN Jiang-feng
	LU Jin-hua
	PAN Yong-hao
	JIANG Yang
	FU Jian-fei

Cite this article:

YING Ming-liang,SHU Jin-er,PAN Jiang-feng, et al. The value of diffusion-weighted imaging based on monoexponential and biexponential model in#br# differentiating benign and malignant hepatic hypervascular lesions[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(1): 39-43.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I1/39

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