ROI和ADC值标准差在预测鼻咽癌近期疗效中的相关分析

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Abstract Objective: To identify the optimal ADC value parameter by evaluating the relationship between different ADC values by ROI and the short-term therapeutic effect of chemoradiation in nasopharyngeal carcinoma. Methods: Fifty-three cases of nasopharyngeal carcinoma patients were performed MR diffusion weighted imaging with b value(0, 800) s/mm2. To obtain 4 ADC value parameters(ADC1-min, ADC1-mean, ADC1-max, ADC1-sd) by A setting(ROI including the entire tumor foci) and obtain 3 ADC value parameters(ADC2-min, ADC2-mean, ADC2-max) by B setting(ROI with 2～3 mm diameter in tumor solid portion). Fifty-three cases were divided into the sensitive group and resistant group according to the size of the primary nasopharyngeal carcinoma after radiotherapy combined with neoadjuvant chemotherapy. To analyze the relationship between 7 parameters and find the best parameter through the Az value of ROC curve and its related factors. Results: Fifty-three cases were attributed to the sensitive group in 35 cases and the resistant group in 18 cases. There were significant difference(t=2.618, 4.809, 2.337, 2.093; P=0.012, 0.000, 0.023, 0.041) among ADC1-mean((0.875±0.114, 0.962±0.116)×10-3 mm2/s), ADC1-sd((0.336±0.075, 0.436±0.066)×10-3 mm2/s), ADC2-min((0.623±0.124, 0.548±0.077)×10-3 mm2/s), ADC2-max((1.234±0.148, 1.320±0.131)×10-3 mm2/s) in two group. And no significant difference(t=1.665, 1.914, 0.801; P=0.102, 0.061, 0.427) in ADC1-min((0.554±0.088, 0.512±0.084)×10-3 mm2/s), ADC1-max((1.512±0.214, 1.630±0.215)×10-3 mm2/s), ADC2-mean((0.856±0.092, 0.877±0.083)×10-3 mm2/s). The Az values of ADC1-mean, ADC1-sd, ADC2-min and ADC2-max were 0.725, 0.864, 0.676, 0.662. There was significant positive correlation(F=4.425, P=0.008) between ADC1-sd and T stage(T1～T4, (0.263±0.102, 0.342±0.081, 0.394±0.062, 0.404±0.096）×10-3 mm2/s), and no significant correlation between ADC1-sd and age, sex and pathological type. Conclusion: The standard deviation of ADC value obtained from ROI including whole nasopharyngeal carcinoma primary tumor has a greater value for predicting the short-term therapeutic effect, which is closely related to the T staging.

Key words： Nasopharyngeal neoplasms Treatment outcome Magnetic resonance imaging

Received: 06 June 2016

PACS:	Ｒ739.62
	Ｒ739.63
	Ｒ445.2

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	Articles by authors
	LI Wei
	TANG Ri-jie
	PENG Jun-qin
	LI Jian-sheng

Cite this article:

LI Wei,TANG Ri-jie,PENG Jun-qin, et al. The analysis of ADC value’s standard deviation and ROI for prediction the short-term#br# therapeutic effect in nasopharyngeal carcinoma[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(2): 85-88.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I2/85

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