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| Application of multi-parametric magnetic resonance imaging in the diagnosis of early prostate cancer |
| ZHANG Xu-hui, LIANG Wen, QUAN Xian-yue, ZHANG Xu-chang, LIN Ting |
| Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China |
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Abstract Objective: To evaluate the diagnostic value of multi-parametric MRI for early prostate cancer. Methods: One hundred patients with prostatic diseases were scanned with MRI, all cases were pathological diagnosis as the gold standard, and they underwent T2WI, DWI and DCEI. Four protocols were formed by combination of above three technologies: T2WI (protocol 1), T2WI+DWI(protocol 2), T2WI+DCEI(protocol 3), T2WI+DWI+DCEI(protocol 4). The image data was diagnosed and made contrast with pathological findings. The AUC value of each protocol in the diagnosis of prostate cancer was compared with Z-test, and the sensitivity, specificity and accuracy for each protocol were calculated. Results: In the four protocols, the sensitivity, specificity and accuracy for protocol 4 in the diagnosis of prostate cancer were the highest(92.6%, 88.9% and 90%), the sensitivity, specificity and accuracy for protocol 1 were the lowest(68.5%, 63.0% and 66%). The AUC value of 4 protocols in descending order: protocol 4(0.916), protocol 2(0.908), protocol 3(0.870) and protocol 1(0.697). There were significant differences in AUC values between protocol 1 and 2, protocol 1 and 3, protocol 1 and 4(P＜0.05). There were not significant differences in AUC values between protocol 2 and 3, protocol 2 and 4, protocol 3 and 4(P＞0.05). Conclusion: T2WI+DWI, T2WI+DCEI and T2WI+DWI+DCEI have highly diagnostic value for early prostate cancer, the clinical value of T2WI+DWI is higher than that of T2WI+DCEI, and T2WI+DWI+DCEI is the best diagnostic efficiency.
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Received: 23 May 2016
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