低剂量全脑CTP在急性脑梗死疗效评估中的价值

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Abstract Objective: To explore the value of 128-slice spiral CT low doses whole-brain CT perfusion imaging(CTP) with 70 kV, 100 mAs in evaluating the treatment response of acute cerebral infarction. Methods: Conventional cerebral CT scanning and the low dose whole-brain CTP were performed on 23 patients with acute cerebral infarction within 24 hours. Seven patients underwent emergency intravenous thrombolysis treatment, and 16 patients underwent routine drug treatment. All patients were reexamined by the same schedule after 7~10 days’ treatment, the cerebral perfusion parameters of central and edge region, including the relative cerebral blood flow(rCBF), relative cerebral blood volume(rCBV), relative time to peak(rTTP) and relative mean transit time(rMTT), were compared before and after treatment. Results: Abnormal low perfusion changes corresponding to clinical symptoms were found in all 23 patients by emergency low doses whole-brain CTP. After 7~10 days’ treatment, the low dose whole-brain CTP showed that the ranges of low perfusion in 21 patients were narrowed, and 2 cases were expanded after treatment. After intravenous thrombolysis treatment, there was statistically significant difference in rCBF of the ischemic central region before and after treatment(P<0.05), and there was no statistically significant difference in rCBV(P>0.05). After routine drug treatment, there was no statistically significant difference in rCBF and rCBV of the ischemic central region(P>0.05). After both intravenous thrombolysis treatment and routine drug treatment, statistically significant differences were found in rCBF, rTTP and rMTT of the ischemic marginal region(P<0.05). No significant difference was detected in rCBV of the ischemic marginal region(P>0.05). Conclusion: The low doses whole-brain CTP could significantly reduce the effective radiation dose, meanwhile, it could not only diagnose acute cerebral infarction but also observe the cerebral hemodynamic changes before and after treatment, combining with routine CT scan and CTA, which provide comprehensive imaging basis for evaluating the therapeutic effect of acute cerebral infarction.

Key words： Brain infarction Thrombolytic therapy Tomography, spiral computed

Received: 27 July 2016

PACS:	Ｒ743.33
	Ｒ814.42

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	Articles by authors
	ZHU Jie1
	ZHANG Bei2
	SONG Bin1
	WEI Ran1
	WENG Ying-feng1

Cite this article:

ZHU Jie1,ZHANG Bei2,SONG Bin1, et al. The value of low doses whole-brain CTP in acute cerebral infarction curative effect evaluation[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(3): 157-161.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I3/157

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