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| The correlation between renal hemodynamics and HbA1c, oxidation material in#br#
T2DM patients with normal renal function |
| WANG Jiao1, GUAN Qing-hua2, ZHOU Yue-hong1 |
1. Department of Endocrinology, the Center Hospital Affiliated to Shenyang Medical College, Shenyang 110024, China;
2. Department of Endocrinology, the Fourth Hospital of People, Shenyang 110031, China |
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Abstract Objective: Comparing the renal hemodynamics and function between the healthy people and the T2DM patients with normal renal function, and to research the correlation between renal index and HbA1c, oxidative index in T2DM patients during the preclinical stage of diabetic nephropathy(DN). Method: We selected 50 healthy people and 80 T2DM patients with normal renal function, then detected and compared the renal hemodynamics(intrarenal RI) and function, HbA1c, oxidative index (ROS, MDA, GSH-PX, and SOD) in the two groups. Then we evaluated the correlation between renal index and HbA1c, oxidative index. Results: The ROS, MDA, GFR, Cr, BUN and AER in the healthy people were lower than T2DM patients(P<0.05), and SOD, GSH-Px were higher than T2DM patients(P<0.05). The renal parameters were positively correlated with HbA1c and diabetes duration in large, but only the correlations of the bilateral kidney RI, GFR and to HbA1c and diabetes duration had statistical significance(P<0.05). The correlation between renal parameters and HbA1c had no statistical significance(P>0.05) in the control group. The correlation analysis between the HbA1c and RI, GFR, Cr, BUN, AER had positive correlation; the correlation analysis between the ROS, MDA and RI, GFR, Cr, BUN, AER had positive correlation; the correlation analysis between the SOD, GSH-Px and RI, GFR, Cr, BUN, AER had negative correlation. The multiple linear regression analysis between the renal function and oxidative related substances had no statistical significance(P>0.05), except the RI and GFR(P<0.05). Conclusion: The T2DM patients had the changes of intrarenal hemodynamics during the early period, the HbA1c and oxidative index can be used to evaluate the damage of intrarenal hemodynamics, and these index provide directions of diagnosis and therapy to us.
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Received: 15 August 2016
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