青年女性乳腺癌特征及影像检查手段效能评价

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Abstract Objective: This is a retrospective study which analyzed the clinical, pathological and radiological information of young women with pathological confirmed breast cancer(≤35 years) in the past four years in our hospital to evaluate the diagnostic value of various imaging methods. Methods: Retrospective analyzed 174 patients(under 35 years old) with 180 pathological confirmed breast cancer lesions in our hospital from January 2011 to December 2014(the average age was 31.6). All patients underwent ultrasound, and 89/174 patients underwent pre-operation mammography, and 21/174 underwent dynamic contrast-enhanced MRI. The status of first clinical symptoms, pathological type, immunohistochemically result, lymph node metastasis, breast imaging performance characteristics, the classification of Breast Imaging Reporting Data System were analyzed. Results: The majority clinical symptom of breast cancer in young women is breast masses which were found occasionally or by health examination(94/174, 54.0%). The main histological type is invasive ductal carcinoma(148/180, 82.2%), and Ⅱ/Ⅲ grade carcinoma accounted for majority of invasive ductal carcinoma(118/148, 79.7% and 20/148, 13.5%). Axillary lymph node-positive rate is high(55/140, 39.3%). Immunohistochemical results showed that the expression level of hormone receptor is low, 36.2% of breast cancer expressed estrogen receptor negative(63/174), 33.3% of breast cancer expressed progesterone receptor negative(58/174); 58.6% of breast cancers was Luminal A type(82/140). Mammography findings maily performed as mass (or with calcification)(52/78, 66.7%), with high density, irregular, blurred edges. The sensitivity and specificity of the breast ultrasound are 100% and 97.1%, respectively and of mammography are 96.6% and 87.6%, respectively, and of dynamic contrast-enhanced breast MRI are both 100%. Conclusions: Breast cancer in young women usually showed breast masses with no symptoms as the main clinical manifestation. The main pathologic type is high-level(Ⅱ, Ⅲ grade) invasive ductal carcinoma, with high lymph node metastasis rate, high ER, PR negative rate, and majority immunohistochemistry type of breast cancer is Luminal A type. The main characteristics of breast cancer mammography images are irregular shape, blurred edge and high density mass(with calcification). The sensitivity and specificity of breast ultrasound is relatively high, which should be taken as the main screening tool for breast cancer in young women. When faced with suspected malignant lesions, joint applying two or more imaging approaches could improve the specificity of diagnosis and avoid unnecessary biopsies and surgery.

Key words： Breast neoplasms Mammography Ultrasonography, Doppler, color Magnetic resonance imaging

Received: 04 August 2016

PACS:	Ｒ737.9
	Ｒ445.1
	Ｒ445.2

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	Articles by authors
	LIU Dan-qing1
	ZHANG Wei1
	WANG Hui-ying1
	HAN Lu2
	LV Dong-jun1

Cite this article:

LIU Dan-qing1,ZHANG Wei1,WANG Hui-ying1, et al. The features of breast cancer in young women and the diagnostic efficacy of imaging means[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(5): 331-336.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I5/331

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