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| PET/CT in the diagnosis of giant cell tumor |
| SHEN Zhi-hui, XU Bai-xuan, GUAN Zhi-wei, LEI Ji-xiao, YANG Hui, XU Xiao-dan, LIU Ya-chao |
| The Chinese People’s Liberation Army General Hospital, Beijing 100853, China |
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Abstract Objective: To analyze the diagnostic value of 18F-FDG PET/CT in giant cell tumor(GCT). Methods: We retrospectively analyzed the clinical data and PET/CT images of 11 cases of GCT patients confirmed by pathology from orthopaedic department of the PLA general hospital. Characteristics and advantages of PET/CT in the diagnosis of GCT were summarized. Results: Among these 11 cases of GCT, the giant cell tumors occured at different sites: 3 cases in cervical vertebra, 2 cases in thoracic and lumbar vertebra and 4 cases in limbs long bone. There were 2 cases of postoperative recurrence and 2 cases of metastasis. The characteristics of PET/CT imaging of the 11 cases of GCT were as the following: 11 cases of GCT had various degrees of FDG uptake, with the average SUVmax of 10.15±4.42. All of the 11 cases of GCT showed osteolytic bone destruction in transverse CT images, including 3 cases with calcification and bone sclerosis, 8 cases with expansive growth, 7 cases with eccentric expansion, 6 cases with soft tissue mass, 2 cases with neurysmal bone cyst. According to the pathology classification, there were 4 cases of grade Ⅰ, with an average SUVmax of 7.73±3.15 and 7 cases of grade Ⅱ/Ⅲ, with an aerage SUVmax of 12.17±4.45. Conclusion: Whole body 18F-FDG PET/CT performs an important role in the diagnosis of GCT. The characteristic manifestations of GCT in 18F-FDG PET/CT can help in early detection of metastasis and exclusion of malignant diseases, so that to guide clinical management of GCT.
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Received: 26 September 2016
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[1]Wuelling M, Engels C, Jesse N, et al. The nature of giant cell tumor of bone[J]. J Cancer Res Clin Oncol, 2001, 127(8): 467-474.
[2]Xing R, Yang J, Kong Q, et al. Giant cell tumor of bone in the appendicular skeleton: an analysis of 276 cases[J]. Acta Orthop Belg, 2013, 79(6): 731-737.
[3]Jaffe HL, Lichtenstein L, Portis RB. Giant Cell Tumor of Bone: Its Pathologic appearance, Grading, Supposed Variants and Treatment[J]. Arch Pathol, 1940, 30(2): 993.
[4]Bertoni F, Bacchini P, Staals EL. Malignancy in giant cell tumor of bone[J]. Cancer, 2003, 97(10): 2520-2529.
[5]瘳金生，杨荣，李志，等. 骨巨细胞瘤CT与MR对照[J]. 中外医疗，2015，6（17）：177-180.
[6]Murphey MD, Nomikos GC, Flemming DJ, et al. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic pathologic correlation[J]. Radiographics, 2001, 21(5): 1283-1309.
[7]张秀宾，姚晓群，杨广夫. 骨巨细胞瘤的影像学诊断[J]. 陕西医学杂志，2013，42（10）：1384-1385.
[8]Marui T, Yamamoto T, Yoshihara H, et al. Denovo malignant transformation of giant cell tumor of bone[J]. Skelet Radiol, 2001, 30(2): 104-108.
[9]O’Connor W, Quintana M, Smith S, et al. The hypermetabolic giant: 18F-FDG avid giant cell tumor identified on PET-CT[J]. J Radiol Case Rep, 2014, 8(6): 27-28.
[10]苑欣然，左玉强，孟庆春，等. 骨巨细胞瘤影像学表现[J]. 河北医药，2015，37（14）：2175-2176.
[11]McDonald D, Sim F, McLeod R, et al. Giant cell tumor of bone[J]. J Bone Joint Surg, 1986, 68(2): 235-242.
[12]Raskin KA, Schwab JH, Mankin HJ, et al. Giant cell tumor of bone[J]. J Am Acad Orthop Surg, 2013, 21(2): 118-126.
[13]杨毅，郭卫，杨荣利，等. 地诺单抗治疗复发或难治骨巨细胞瘤疗效和安全性的初步观察[J]. 中国骨与关节杂志，2016，5（1）：19-23.
[14]Szendroi M. Giant cell tumor of bone[J]. J Bone Joint Surg Br, 2004, 86(1): 5-12.
[15]Klenke FM, Wenger DE, Inwards CY, et al. Giant cell tumor of bone: risk factors for recurrence[J]. Clin Orthop Relat Res, 2011, 469(2): 591-599.
[16]Makis W, Alabed YZ, Nahal A, et al. Giant Cell Tumor Pulmonary Metastases Mimic Primary Malignant Pulmonary Nodules on (18)F-FDG PET/CT[J]. Nucl Med Mol Imaging, 2012, 46(2): 134-137. |
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