多b值弥散加权成像与动脉自旋标记评估轻度认知功能障碍海马灌注的对比研究

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Abstract Objective: To compare and analyze the clinical application value of both the multiple b value diffusion weighted imaging(MB-DWI) and arterial spin labeling(ASL) imaging for evaluating changes of hippocampus perfusion of patients with mild cognitive impairment. Methods: Based on diagnostic criteria and exclusion criteria, 40 subjects(include 20 mild cognitive impairment and 20 elderly cognitively healthy) underwent routine MRI with MRA, ASL and MB-DWI. Bilateral hippocampus areas were selected as regions of interest and local cerebral blood flow(rCBFASL) were measured by using ASL. Parameters measured by MB-DWI were fast ADC-mono, fraction of fast ADC-mono, fast ADC-bi, and fraction of fast ADC-bi. t test was performed for bilateral hippocampus areas between MCI group and NC group. Pearson correlation analysis was performed for changes of relative values(fast ADC-mono, fraction of fast ADC-mono, fast ADC-bi, and fraction of fast ADC-bi) of parameters of MB-DWI and rCBFASL. Results: The rCBFASL of MCI group was lower than that of NC group, and the difference was significant(P<0.05). There were significantly differences among of fast ADC-mono, fraction of fast ADC-mono and fraction of fast ADC-bi between the MCI group and NC group(P<0.05). The fast ADC-bi of MCI group was lower than that of NC group, and the difference was not statistically significant(P<0.05). Except fast ADC-bi group, the differences between fast ADC-mono, fraction of fast ADC-mono, fraction of fast ADC-bi of bilateral hippocampus areas and rCBFASL were statistically significant(P<0.05). Conclusion: The results of MB-DWI and ASL for changes of hippocampus perfusion of patients with mild cognitive impairment are consistent, which can be used for evaluating changes of brain perfusion in mild cognitive impairment and are helpful for clinical diagnosis and treatment.

Key words： Cognition disorders Magnetic resonance imaging

Received: 17 November 2016

PACS:	Ｒ749.1
	Ｒ445.2

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	Articles by authors
	RU Yan-hui1
	WANG Xin-yi2
	YANG Zhi-qiang2
	DONG Dong2

Cite this article:

RU Yan-hui1,WANG Xin-yi2,YANG Zhi-qiang2, et al. Comparative study on evaluating hippocampus perfusion of patients with mild cognitive impairment by multiple b value diffusion weighted imaging and arterial spin labeling imaging[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(8): 533-537.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I8/533

[1]Eshkoor SA, Hamid TA, Mun CY, et al. Mild cognitive impairment and its management in older people[J]. Clin Interv Aging, 2015, 10(4): 687-693.
[2]Lacalle-Aurioles M, Navas-Sánchez FJ, Alemán-Gómez Y, et al. The Disconnection Hypothesis in Alzheimer’s Disease Studied Through Multimodal Magnetic Resonance Imaging: Structural, Perfusion, and Diffusion Tensor Imaging[J]. J Alzheimers Dis, 2016, 50(4): 1051-1064.
[3]Petcharunpaisan S, Ramalho J, Castillo M. Arterial spin labeling in neuroimaging[J]. World J Radiol, 2010, 2(10): 384-398.
[4]Petersen RC, Caracciolo B, Brayne C, et al. Mild cognitive impairment: a concept in evolution[J]. J Intern Med, 2014, 275(3): 214-228.
[5]Stephan B, Hunter S, Harris D, et al. The neuropathological profile of mild cognitive impairment(MCI): a systematic review[J]. Mol Psychiatr, 2012, 17(11): 1056-1076.
[6]Desikan RS, Cabral HJ, Settecase F, et al. Automated MRI measures predict progression to Alzheimer’s disease[J]. Neurobiol Aging, 2010, 31(8): 1364-1374.
[7]Zhu X, Smith MA, Honda K, et al. Vascular oxidative stress in Alzheimer disease[J]. J Neurol Sci, 2007, 257(1-2): 240-246.
[8]Tosun D, Schuff N, Jagust W, et al. Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer’s Disease Continuum[J]. Neurodegener Dis, 2015, 16(1-2): 87-94.
[9]Habert MO, Horn JF, Sarazin M, et al. Brain perfusion SPECT with an automated quantitative tool can identify prodromal Alzheimer’s disease among patients with mild cognitive impairment[J]. Neurobiol Aging, 2011, 32(1): 15-23.
[10]Lacalle-Aurioles M, Mateos-Pérez JM, Guzmán-De-Villoria JA, et al. Cerebral blood flow is an earlier indicator of perfusion abnormalities than cerebral blood volume in Alzheimer’s disease[J]. J Cereb Blood Flow Metab, 2014, 34(4): 654-659.
[11]Wirth M, Binette AP, Brunecker P, et al. Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients[J]. J Cereb Blood Flow Metab, 2017, 37(3): 814-824.
[12]Alsop DC, Casement M, Bazelaire CD, et al. Hippocampal hyperperfusion in Alzheimer’s disease[J]. Neuroimage, 2008, 42(4): 1267-1274.
[13]Federau C, Maeder P, O’brien K, et al. Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging[J]. Radiology, 2012, 265(3): 874-881.
[14]Lemke A, Stieltjes B, Schada LR, et al. Toward an optimal distribution of b values for intravoxel incoherent motion imaging[J]. Magn Reson Imaging, 2011, 29(6): 766-776.
[15]Mulkern RV, Barnes AS, Haker SJ, et al. Biexponential characterization of prostate tissue water diffusion decay curves over an extended b-factor range[J]. Magn Reson Imaging, 2006, 24(5): 563-568.
[16]Wu WC, Chen YF, Tseng HM, et al. Caveat of measuring perfusion indexes using intravoxel incoherent motion magnetic resonance imaging in the human brain[J]. Eur Radiol, 2015, 25(8): 2485-2492.
[17]Liu T, Han Y, Tang L, et al. Detection of chronic brain damage by diffusion-weighted imaging with multiple b values in patients with type 2 diabetes[J]. Medicine(Baltimore), 2016, 95(35): 4726-4731.
[18]林园凯，王奕，张宗军. 不同回波时间对扩散加权成像人脑体素不相干运动参数的影响[J]. 中国医学影像技术，2015，31（12）：1902-1906.
[19]Yao Y, Zhang S, Tang X, et al. Intravoxel incoherent motion diffusion-weighted imaging in stroke patients: initial clinical experience[J]. Clin Radiol, 2016, 71(9): 938-943.