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| A correlation study of breast cancer TIC types and ER/PR or CerbB-2 |
1. Department of Imaging Diagnosis, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, China;
2. The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China |
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Abstract Objective: To investigate the correlation of dynamic contrast-enhanced time-signal intensity curve(TIC) of breast cancer and biological factors included ER/PR, CerbB-2. Methods: Dynamic contrast-enhanced MRI(DCE-MRI) imaging data and immunohistochemical results of 33 patients with breast cancer proved by operation and pathology were retrospectively analyzed, then the TIC was drawn for 33 lesions and ER/PR and CerbB-2 status were analyzed, a chi-square test was used to explore the correlation between TIC types and biological factors of breast cancers. Results: Among the 33 lesions, 30 lesions were invasive ductal carcinoma, the rest of the cases were invasive lobular carcinoma(1), sebaceous gland carcinoma(1) and ductal carcinoma in situ(1) respectively. Thirty-one masses enhancement lesions and 2 focal enhancement lesions were idenfied. The main type of TIC were type Ⅱ and type Ⅲ, and there were 12 lesions that behave as both type Ⅱ and type Ⅲ, therefore 23 cases with type Ⅱ and 22 cases with type Ⅲ. For the immunohistochemical results, 22 lesions were ER/PR positive, and 11 lesion were negative; 14 lesions were CerbB-2 positive, 19 were negative. There was no correlation between TIC types and biological factors include ER/PR(χ2=0.012, P>0.05) and CerbB-2(χ2=0.030, P>0.05) of breast cancers. Conclusion: There was no correlation between TIC of breast cancer and biological factors(ER/PR, CerbB-2).
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Received: 24 October 2016
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