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| Comparison of TOF and PSF PET image reconstruction technology’s influence on quantitative parameters of tumor lesions |
1. Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China;
2. Department of Nuclear Medicine, Tianjin Tumour Hospital, Tianjin 300060, China;
3. Department of Nuclear Medicine, the Inner Mongolia Autonomous Region People’s Hospital, Hohhot 010017, China |
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Abstract Objective: To contrastively analyze the effect of TOF-PET and PSF-PET reconstruction technique for 18F-FDG metabolic parameter of different part of the body and different of malignant lesions. Materials and methods: To analyze respectively 270 cases of 18F-FDG PET/CT-treated primary malignant tumor infected individuals in several hospitals, 121 male patients and 149 female patients with an average age of 59.07±11.82(29~87 years old), 23.92±3.35(16.61~34.34) of BMI, 97 cases of chest tumor, 62 of abdominal tumor, 104 of pelvic tumor and 9 of superficial tumor, and (4.16±2.27) cm(0.5~15.2 cm) of Dmax. Reconstruct the PET/CT data according to VUE Point HD, TOF+VUE Point HD, SharpIR+VUE Point HD and TOF+SharpIR+VUE Point HD were done, in which VUE Point HD(GE Healthcare) is 3D iteration reconstruction technique and SharpIR(GE Healthcare) is the PET image reconstruction technique based on PSF technology. We used the PET VCAR on AW station for image processing and measurement of 18F-FDG metabolic parameter(SULmean, SULmax, SUVmean, SUVmax) to calculate the change rate(%). We used independent sample to analyze the comparation of change rate of TOF, PSF and TOF+PSF parameters. Result: Both TOF and PSF are useful to improve the metabolic parameters of all malignant lesions, and TOF+PSF is the most significant. For chest lesions, PSF is superior to TOF to the improve SUVmax, 8.96% vs 5.26%(P<0.05), which is similar in superfacial lesions. Improvement of SULmax, SUVmean and SUVmax by PSF is better than that by TOF, which is 9.22% vs 1.22%, 8.56% vs 1.78% and 9.33% vs 1.11%(P<0.05). But for pelvic lesions, TOF is superior to PSF to improve SULmax and SUVmax, which is 18.72% vs 12.29% and 20.69% vs 15.41%(P<0.05). For abdominal lesions, there is no significant difference in Metabolic index increase between TOF and PSF(P>0.05). When BMI>25, improvement of SULmax and SUVmax by TOF is better than that by PSF, which is 10.45% vs 6.16% and 10.27% vs 6.43% respectively(P<0.05). But when Dmax≤2.0 cm, PSF is significantly superior to TOF to improve SUVmax, which is 11.68% vs 4.78%(P<0.05). When BMI<25 and Dmax>2.0 cm, no difference appeare between them. Conclusion: Both TOF and PSF can improve the metabolic parameter of malignant lesions and TOF+PSF is the most significant one. But as for chest and superfacial lesions, especially for smaller lesions, PSF is obviously better than TOF. On the contrary, for pelvic lesions, when BMI>25, TOF has more advantage.
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Received: 10 November 2016
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